volume 66, issue 8, P5161-5167 1992
DOI: 10.1128/jvi.66.8.5161-5167.1992
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A L Burkhardt, J B Bolen, E Kieff, R Longnecker

Abstract: In latently infected growth-transformed human lymphocytes, Epstein-Barr virus (EBV) encodes two integral plasma membrane proteins: LMP1, which constitutively induces B-lymphocyte activation and intercellular adhesion, and LMP2A, which associates with LMP1 and is a tyrosine kinase substrate. We now demonstrate that LMP2A associates with src family protein tyrosine kinases, particularly lyn kinase, in nonionic detergent extracts of transfected B lymphoma cells or in extracts of EBV-transformed B lymphocytes. The…

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