Abstract:Notch signaling facilitates inducible Foxp3+ regulatory T cells (iTreg) differentiation. Epigenetic modifications, which include histone modifications, are critical in cell differentiation. Recent genome-wide studies showed that iTreg have increased trimethylation on histone H3 at lysine 4 (H3K4me3) around Foxp3 loci, but the role of Notch signaling and its underlying epigenetic mechanisms remain elusive. Here we report that Delta-like ligand 4 (Dll4) but not Jagged1 can activate Notch signaling, facilitate Fo… Show more
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