An endoplasmic reticulum-targeting fluorescent probe for imaging ˙OH in living cells

Zhao, Yanyan; Li, Hongyu; Chai, Ziyin; Li, Xiaohua; Ma, Huimin

doi:10.1039/d0cc00233j

Cited by 22 publications

(5 citation statements)

References 37 publications

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“…9), for imaging • OH in living cells. 85 In the absence of • OH, the probe itself exhibited stable fluorescence at 446 nm, whereas when • OH was added, the emission at 446 nm increased immediately and continuously. This probe was highly selective to • OH and was stable in different pH buffer and solvents.…”

Section: Er-targetable Fluorescent Probesmentioning

confidence: 97%

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

Tang

Zhai

et al. 2022

Analyst

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Section: Er-targetable Fluorescent Probesmentioning

confidence: 97%

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

Tang

Zhai

et al. 2022

Analyst

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“…Observation with fluorescent reagents (e.g., dihydrorhodamine, coumarin-3-calboxylic acid, and endoplasmic reticulum (ER)-targeting OH • probe) has revealed intracellular localization of the generated OH • . Such studies have reported that ER by the Fenton reaction [ 53 , 54 ] regulates hypoxia-inducible gene expression. ER stress has been reported to regulate more than one-third of all proteins made in the cell in synthesis, folding, and structural maturation [ 55 ].…”

Section: Fenton Reaction In Bodymentioning

confidence: 99%

Current Use of Fenton Reaction in Drugs and Food

Abe

Miyazawa

2022

Molecules

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Iron is the most abundant mineral in the human body and plays essential roles in sustaining life, such as the transport of oxygen to systemic organs. The Fenton reaction is the reaction between iron and hydrogen peroxide, generating hydroxyl radical, which is highly reactive and highly toxic to living cells. “Ferroptosis”, a programmed cell death in which the Fenton reaction is closely involved, has recently received much attention. Furthermore, various applications of the Fenton reaction have been reported in the medical and nutritional fields, such as cancer treatment or sterilization. Here, this review summarizes the recent growing interest in the usefulness of iron and its biological relevance through basic and practical information of the Fenton reaction and recent reports.

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“…As an important organelle in cells, endoplasmic reticulum plays a key role in cell metabolism, protein synthesis and transmission of intermediates and signal molecules (Zhang M.-M. et al, 2020;Zhao et al, 2020). Tang's group reported an AIE material 9 based on cyanostillbene skeleton by simple functionalization ( Figure 3A) (Alam et al, 2020).…”

Section: In Vitro Cell Imagingmentioning

confidence: 99%

Fluorescent AIE-Active Materials for Two-Photon Bioimaging Applications

Lü

Liu

et al. 2020

Front. Chem.

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Fluorescence imaging has been widely used as a powerful tool for in situ and real-time visualization of important analytes and biological events in live samples with remarkably high selectivity, sensitivity, and spatial resolution. Compared with one-photon fluorescence imaging, two-photon fluorescence imaging exhibits predominant advantages of minimal photodamage to samples, deep tissue penetration, and outstanding resolution. Recently, the aggregation-induced emission (AIE) materials have become a preferred choice in two-photon fluorescence biological imaging because of its unique bright fluorescence in solid and aggregate states and strong resistance to photobleaching. In this review, we will exclusively summarize the applications of AIE-active materials in two-photon fluorescence imaging with some representative examples from four aspects: fluorescence detection, in vitro cell imaging, ex vivo tissue imaging, and in vivo vascular imaging. In addition, the current challenges and future development directions of AIE-active materials for two-photon bioimaging are briefly discussed.

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An endoplasmic reticulum-targeting fluorescent probe for imaging ˙OH in living cells

Abstract: A new ER-targeting fluorescent probe for ˙OH is developed and applied to imaging ˙OH generation as well as lipid droplet formation in ER stress.

Cited by 22 publications

References 37 publications

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

Current Use of Fenton Reaction in Drugs and Food

Fluorescent AIE-Active Materials for Two-Photon Bioimaging Applications

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