An Elevated METS-IR Index Is Associated With Higher Asthma Morbidity and Earlier Age of First Asthma in US Adults: Results Based on a Cross-Sectional Study

Abstract

ObjectiveThe purpose of this study was to evaluate whether there is a correlation between the METS-IR index and asthma among Americans.MethodsIn an attempt to establish the relationship between the METS-IR index and asthma prevalence and age at first onset of asthma, we conducted a logistic regression analysis, subgroup analysis, and dose-response curve analysis using the National Health and Nutrition Examination Survey (NHANES) database.ResultsIn model 3, each unit increase in METS-IR index led to 1.5% increase in asthma prevalence (OR= 1.015, 95% CI: 1.012, 1.018) and an earlier age of onset of asthma by 0.057years (β= -0.057, 95% CI: -0.112, -0.002).Stratified analysis determined that an increase in METS-IR index was associated with asthma prevalence in almost all subgroups, except in the group where it was not known whether a blood relative had asthma, and a positive linear relationship was found between METS-IR index and asthma prevalence, as well as a linear negative relationship with age at asthma onset.ConclusionDespite the fact that a direct causal relationship cannot be demonstrated, a higher METS-IR index is positively related to asthma prevalence and correspondingly may result in asthma onset at younger ages.

Association of METS-IR index with prevalence of gallbladder stones and the age at the first gallbladder stone surgery in US adults: A cross-sectional study

“…According to a Korean study ( 15 ), insulin resistance is associated with gallstones in non-hypertensive and non-diabetic individuals. Chen et al ( 16 ) found that elevated METS-IR index was associated with increased asthma prevalence in non-hypertensive and non-diabetic populations, while Shen et al ( 6 ) had similar findings in their study of METS-IR index and kidney stone prevalence. Although the above two studies were conducted on different subjects, they also reflect that our findings may be correct.…”

“…The METS-IR index was first reported in 2018 as a practical and intuitive predictor of IR for clinical decision-making ( 6 , 16 ). It has now been shown that IR can cause gallbladder stones to develop or become exacerbated in many studies, and visceral obesity and hepatic insulin resistance may be central to promoting cholesterol bile supersaturation and gallstone formation ( 21 ).…”

Higher visceral adiposity index was associated with an elevated prevalence of gallstones and an earlier age at first gallstone surgery in US adults: the results are based on a cross-sectional study

“…Adjusted for all covariates except the effect modifier. Korean study, metabolic syndrome was associated with gallstone development in non-hypertensive and non-diabetic patients The study by Chen (39) showed that the elevated metabolic syndrome specific index was associated with increased asthma prevalence in non-hypertensive and non-diabetic populations, while Shen's study found a correlation between the METS-IR index and the prevalence of kidney stones in non-hypertensive and non-diabetic populations (40). Our results showed a strong correlation between the prevalence of gallstones in the nonhypertensive group (OR = 1.33, 95% CI: 1.12, 1.57) and in the hypertensive group (OR = 1.27, 95% CI: 1.07, 1.50).…”

Association between a metabolic score for insulin resistance and hypertension: results from National Health and Nutrition Examination Survey 2007–2016 analyses

“…The arithmetic formula of METS-IR was (Ln[(2×FBG(mg/dL))+TG(mg/dL)]×BMI(kg/m²))/[Ln(HDL-C(mg/dL))] ( 23 ). After an 8.5-hour overnight fast, morning blood samples were collected to measure fasting glucose and total triglyceride levels.…”