An electrospray mass spectrometry study of some metal-ion cage complexes

Ralph, Stephen F.; Sheil, Margaret M.; Hick, Larry A.; Geue, Rodney J.; Sargeson, Alan M.

doi:10.1039/dt9960004417

Cited by 30 publications

(20 citation statements)

References 30 publications

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“…(Hao & March, 2001b), but also by the redox reactions which the solvent undergoes at the capillary of the spray (Gatlin, Turecek, & Vaisar, 1994;Wang & Agnes, 1999a,b). Redox reactions may be experienced also by redox-active ligands as N,N-diethyldithiocarbamate and glutathione (Ross, Ikonomou, & Orians, 2000b), and by metal ions as Cu(II) (Xu, Zhang, & Yergey, 1996;Ross et al, 1998;Bartoszek et al, 1999;Lavanant, Hecquet, & Hoppilliard, 1999;Shen & Brodbelt, 1999;Ross, Ikonomou, & Orians, 2000a;Gianelli et al, 2001;Woodcock et al, 2001;Schroder, Weiske, & Schwarz, 2002;Cerchiaro et al, 2004;Lyapchenko et al, 2004;Franski, 2004a), Fe(III) (Mollah et al, 2000;Ross, Ikonomou, & Orians, 2000a;Neubert, Hider, & Cowan, 2002), Cr(VI) (Sahureka, Burns, & von Nagy Felsobuki, 2002), In(III) (Vasca et al, 2003), Co(III) (Ralph et al, 1996b), Ni(II) (Olesik, Thaxton, & Olesik, 1997), Eu(III) and U(IV) (Stewart & Horlick, 1996). Redox reactions may occur also in other parts of the ES chamber and not only at the capillary tip (Gianelli et al, 2001).…”

Section: Possible Solution Perturbationsmentioning

confidence: 99%

Electrospray mass spectrometry (ESI‐MS) in the study of metal–ligand solution equilibria

Marco¹,

Bombi²

2005

Mass Spectrometry Reviews

326

256

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In the 20 years, since the introduction of electrospray mass spectrometry (ESI-MS), the use of this technique in various fields of inorganic, organometallic, and analytical chemistry has been steadily increasing. In this study, the application of ESI-MS to the study of metal-ligand solution equilibria is reviewed (till 2004 included). In a first section, advantages and drawbacks of ESI-MS in this type of application are described. Subsequently, a list of ca. 300 studies is reported, in which ESI-MS was used to give number and stoichiometry of the species at equilibrium, or also to estimate their stability constants. All studies are classified according to the metal ions under examination. Other related applications, such as host-guest interactions and metal ion-protein binding studies, are briefly reviewed as well.

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Section: Possible Solution Perturbationsmentioning

confidence: 99%

Electrospray mass spectrometry (ESI‐MS) in the study of metal–ligand solution equilibria

Marco¹,

Bombi²

2005

Mass Spectrometry Reviews

326

256

View full text Add to dashboard Cite

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“…This approach is based on selective host molecules for specific cationic or anionic guests, which can form ionic adducts with higher molecular mass. Most of the supramolecular complexes investigated by MS involve macrocycles, such as crown ethers and cryptands, which form cationic metal-receptor complexes detectable in positive ion mode [15][16][17][18][19]. Anion supramolecular chemistry [20] is relatively less well developed and oftentimes anion receptors are not as strong as cation receptors in terms of thermodynamic binding constants.…”

mentioning

confidence: 99%

Identification of Anionic Supramolecular Complexes of Sulfonamide Receptors with Cl⁻, NO₃⁻, Br⁻, and I⁻ by APCI-MS

Kavallieratos

Sabucedo

Pau

et al. 2005

J. Am. Soc. Mass Spectrom.

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As part of a mass spectrometric investigation of the binding properties of sulfonamide anion receptors, an atmospheric pressure chemical ionization mass spectrometric (APCI-MS) method involving direct infusion followed by thermal desorption was employed for identification of anionic supramolecular complexes in dichloromethane (CH 2 Cl 2 ). Specifically, the dansylamide derivative of tris(2-aminoethyl)amine (tren) (1), the chiral 1,3-benzenesulfonamide derivatives of (1R,2S)-(ϩ)-cis-1-amino-2-indanol (2), and (R)-(ϩ)-bornylamine, (3), were shown to bind halide and nitrate ions in the presence of (nϪBu) Solutions of receptors and anions in CH 2 Cl 2 were combined to form the anionic supramolecular complexes, which were subsequently introduced into the mass spectrometer via direct infusion followed by thermal desorption. The anionic supramolecular complexes Inorganic ions with small mass-to-charge ratios are typically analyzed by other techniques, such as ion chromatography and capillary electrophoresis, because under normal MS ionization conditions many compounds can produce small ions that can interfere with their detection. There are, however, some notable examples [7,8] that demonstrate the potential of soft ionization methods [9], such as atmospheric pressure chemical ionization mass spectrometry (APCI-MS) and electrospray ionization mass spectrometry (ESI-MS)[10] for analysis of inorganic ions, and ion pairs, such as ammonium nitrate [11].Increased sensitivity for MS analysis of inorganic ions has been achieved by a relatively new and promising strategy, which bridges the fields of mass spectrometry and supramolecular chemistry [12][13][14]. This approach is based on selective host molecules for specific cationic or anionic guests, which can form ionic adducts with higher molecular mass. Most of the supramolecular complexes investigated by MS involve macrocycles, such as crown ethers and cryptands, which form cationic metal-receptor complexes detectable in positive ion mode [15][16][17][18][19]. Anion supramolecular chemistry [20] is relatively less well developed and oftentimes anion receptors are not as strong as cation receptors in terms of thermodynamic binding constants. Moreover, negative ionization is more susceptible to corona discharge [21,22]. Therefore, negative-ion mode MS detection of noncovalent anion-receptor complexes is less common than positive-ion mode, with the examples reported [23][24][25][26][27][28] for the detection of organic explosives. APCI presents some advantages compared with ESI in quantitative analysis such as higher dynamic range, and is considered rugged, easy to operate, and more tolerant of higher buffer concentrations (fewer matrix effects) [31]. Multiply charged species are typically not observed in APCI-MS spectra [1]. Even though APCI is considered a soft ionization method, it has not found the same application in anion supramolecular chemistry as ESI because the larger supramolecular ions are generally not observed. Therefore, successful identification of noncova...

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“…[22] ESMS www.eurjic.orgspectra of compounds 2 and 3 display peaks consistent with the molecular ions corresponding to a loss of H + from the cation, and some peaks consistent with an additional association of chloride anions. ESMS spectra of compounds 4-10 in several cases display multiple peaks, corresponding to the molecular ion in charge states of 2+, 3+ and 4+, which are assigned as successive losses of H + from the parent ion, sometimes accompanied by association of a perchlorate anion.…”

Section: Mass Spectrometrymentioning

confidence: 72%

“…Loss of H + from a coordinated -NH-group of the cage is known and the resolution of the measurements here are sufficient to distinguish this possibility from that of Co-III reduction to Co II in the mass spectrometer, as has also been observed. [22] There also appears to be no cleavage of the disulfide link during volatilisation.…”

Section: Mass Spectrometrymentioning

confidence: 97%

Cages on Surfaces: Thiol Functionalisation of Co^III Sarcophagine Complexes

et al. 2007

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An electrospray mass spectrometry study of some metal-ion cage complexes

Abstract: A series of cationic metal complexes of the bicyclic hexaamine cage compoundfuc-1,

Cited by 30 publications

References 30 publications

Electrospray mass spectrometry (ESI‐MS) in the study of metal–ligand solution equilibria

Electrospray mass spectrometry (ESI‐MS) in the study of metal–ligand solution equilibria

Identification of Anionic Supramolecular Complexes of Sulfonamide Receptors with Cl⁻, NO₃⁻, Br⁻, and I⁻ by APCI-MS

Cages on Surfaces: Thiol Functionalisation of Co^III Sarcophagine Complexes

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An electrospray mass spectrometry study of some metal-ion cage complexes

Abstract: A series of cationic metal complexes of the bicyclic hexaamine cage compoundfuc-1,

Cited by 30 publications

References 30 publications

Electrospray mass spectrometry (ESI‐MS) in the study of metal–ligand solution equilibria

Electrospray mass spectrometry (ESI‐MS) in the study of metal–ligand solution equilibria

Identification of Anionic Supramolecular Complexes of Sulfonamide Receptors with Cl−, NO3−, Br−, and I− by APCI-MS

Cages on Surfaces: Thiol Functionalisation of CoIII Sarcophagine Complexes

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Identification of Anionic Supramolecular Complexes of Sulfonamide Receptors with Cl⁻, NO₃⁻, Br⁻, and I⁻ by APCI-MS

Cages on Surfaces: Thiol Functionalisation of Co^III Sarcophagine Complexes