An electrochemical sensor based on AuPd@FexOy nanozymes for a sensitive and in situ quantitative detection of hydrogen peroxide in real samples

Dai, Mengjiao; Zhu, Qunyan; Han, Dongxue; Niu, Li

doi:10.1039/d2an01509a

“…Colorimetry [93] (Fe-N-C SAN) (5 min) Colorimetry (Fe-N-C SAN) [94] (5 min) Electrochemistry (Pt-Au-bimetallic nano porous electrode) [96] (Snapshot) Electrochemistry (AuPd@Fe x O y NPs/GCE) [97] (Snapshot) -16. Rat Hepatocyte (Ethanol-100 mM)…”

Section: μM (Extracellular)mentioning

confidence: 99%

Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)‐Sensitive Triggers

Kondengadan,

Wang

2024

Angew Chem Int Ed

1

0

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Reactive oxygen species (ROS) are critical for cellular signaling. Various pathophysiological conditions are also associated with elevated levels of ROS. Hence, ROS‐sensitive triggers have been extensively used for selective payload delivery. Such applications are predicated on two key functions: (1) a sufficient magnitude of concentration difference for the interested ROS between normal tissue/cells and intended sites and (2) appropriate reaction kinetics to ensure a sufficient level of selectivity for payload release. Further, ROS refers to a group of species with varying reactivity, which should not be viewed as a uniform group. In this review, we critically analyze data on the concentrations of different ROS species under various pathophysiological conditions and examine how reaction kinetics affect the success of ROS‐sensitive linker chemistry. Further, we discuss different ROS linker chemistry in the context of their applications in drug delivery and imaging. This review brings new insights into research in ROS‐triggered delivery, highlights factors to consider in maximizing the chance for success and discusses pitfalls to avoid.

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“…AuNPs, which are one of the widely used metal nanoparticles, have also garnered attention for application in the detection of target molecules using electrochemical sensors, due to their outstanding electrical conductivity, strong electron transfer ability, and excellent anti-pollution ability. [27][28][29] The prepared Fe-N-C/AuNP nanohybrid not only significantly increased the number of active sites, but also enhanced electrical conductivity, thereby improving the electrochemical performance of the fabricated sensor.…”

Section: Introductionmentioning

confidence: 99%

A novel electrochemical sensor based on an Fe–N–C/AuNP nanohybrid for rapid and sensitive gallic acid detection

Zhang

¹

,

Li

²

,

Hu

³

et al. 2023

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Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)‐Sensitive Triggers

Kondengadan,

Wang

2024

Angewandte Chemie

0

View full text Add to dashboard Cite

Reactive oxygen species (ROS) are critical for cellular signaling. Various pathophysiological conditions are also associated with elevated levels of ROS. Hence, ROS‐sensitive triggers have been extensively used for selective payload delivery. Such applications are predicated on two key functions: (1) a sufficient magnitude of concentration difference for the interested ROS between normal tissue/cells and intended sites and (2) appropriate reaction kinetics to ensure a sufficient level of selectivity for payload release. Further, ROS refers to a group of species with varying reactivity, which should not be viewed as a uniform group. In this review, we critically analyze data on the concentrations of different ROS species under various pathophysiological conditions and examine how reaction kinetics affect the success of ROS‐sensitive linker chemistry. Further, we discuss different ROS linker chemistry in the context of their applications in drug delivery and imaging. This review brings new insights into research in ROS‐triggered delivery, highlights factors to consider in maximizing the chance for success and discusses pitfalls to avoid.

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An electrochemical sensor based on AuPd@Fe_xO_y nanozymes for a sensitive and in situ quantitative detection of hydrogen peroxide in real samples

Abstract: The hydrogen peroxide (H2O2) levels in living organisms and environment have a strong effect on many biological processes inducing cell apoptosis/cell necrosis and wound disinfection. Therefore, it is important to...

Cited by 8 publications

References 43 publications

Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)‐Sensitive Triggers

Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)‐Sensitive Triggers

A novel electrochemical sensor based on an Fe–N–C/AuNP nanohybrid for rapid and sensitive gallic acid detection

Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)‐Sensitive Triggers

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