An electrical model of the cell-electrode interface for high-density microelectrode arrays

Joye, Neil; Schmid, Alexandre; Leblebici, Yusuf

doi:10.1109/iembs.2008.4649214

Cited by 32 publications

(29 citation statements)

References 11 publications

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“…7(a), the frequency has negligible effects on the optimum electrode size. Similar results have been found regarding the cell-electrode distance [23]. However, this optimum size has a strong dependence on the load capacitance, as described in Fig.…”

Section: Transfer Function Of the System For An Electrode Centered Wisupporting

confidence: 88%

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Electrical modeling of the cell–electrode interface for recording neural activity from high-density microelectrode arrays

2009

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a b s t r a c tAccurate electrical models are needed to support the design of modern microelectrode arrays. The point-contact model is presented thoroughly, and an area-contact model is analytically derived in order to model the electrical characteristics of the cell-electrode interface at subcellular resolution. An optimum electrode diameter for recording the electrical activity of neurons is analytically determined at 8 mm, with a cell diameter of 10 mm and a typical load capacitance of 10 pF. Finally, three-dimensional tip electrodes are characterized using the area-contact model. An improvement of the electrical coupling up to 20 dB is observed for small electrodes, in simulation.

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Section: Transfer Function Of the System For An Electrode Centered Wisupporting

confidence: 88%

“…A noise model can be inserted into the model of the electrode, to enable realistic noise simulations of the full system [24]. Ongoing work in this direction is currently performed in order to determine the specifications of a low-noise CMOS amplifier stage (input impedance, input referred noise, etc.…”

Section: Discussionmentioning

confidence: 99%

Electrical modeling of the cell–electrode interface for recording neural activity from high-density microelectrode arrays

2009

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“…Noise arising from the neuron cell such as channel noise is not considered in this study [6], which can not appropriately be described by the noise of electrical circuit elements such as resistors and capacitors. Thus, the equivalent circuit of the attached membrane (R m , C m , and C hd ) is not described in this Section [5].…”

Section: The Modelsmentioning

confidence: 99%

“…1 is considered in this study [5]. It is the standard model used to describe the electrical characteristics of the cell-electrode interface.…”

Section: The Modelsmentioning

confidence: 99%

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A cell-electrode interface noise model for high-density microelectrode arrays

Joye

Schmid

Leblebici

2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-A cell-electrode interface noise model is developed which is dedicated to enable the co-simulation of the cellelectrode electrical characteristics, along with the electronics of novel CMOS-based MEA. The electrode noise is investigated for Pt and Pt black electrodes. It is shown that the electrode noise can be the dominant noise source in the full system. Moreover, Pt black electrodes benefit from up to 5 µV rms decrease of the electrode output noise, for small electrodes. Furthermore, the cell-electrode interface noise spectral density is shown to be 10 dB to 20 dB larger at 1 kHz when a cell is lying on top of the electrode. This increase depends on the neural cell adhesion on the MEA surface.

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Analytical and Numerical Modeling Methods for Electrochemical Impedance Analysis of Single Cells on Coplanar Electrodes

et al. 2014

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Impedance measurements provide basic electrical properties and are used to analyze the characteristics of electrochemical materials for biomedical applications. The extracellular fluid (ECF) in microfluidic devices greatly affects the accuracy of impedance measurements of cells. When a single cell is placed in large amounts of ECF, the electric current mostly passes through the ECF, not the cell. Hence, this work presents a modeling method that is demonstrated in numerical and analytical solutions for eliminating the effect of ECF in coplanar impedance sensors. The proposed modeling method uses fundamental formulas of circuits that include the electrical parameters of the ECF, cytoplasm, and cell membrane. Equivalent circuit models for the coplanar impedance sensor are established to simulate the impedance as well as the measured ones for excitation frequencies in the range of 11–101 kHz. According to the calculation result using the proposed modeling method, the cytoplasm resistance, membrane capacitance, medium resistance, and medium capacitance of HeLa (human cervix adenocarcinoma) cell are 13.5 kΩ, 122.6 pF, 27.9 kΩ, and 337.7 pF, respectively. Moreover, the electric current distribution in the coplanar impedance sensor is investigated using finite element method (FEM) simulation software. The variation in the impedance during measurements with the simultaneous application of an alternating‐current (AC) voltage amplitude of 0.4 Vpp in the fluid volume range of 9–144 µL is also studied.

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An electrical model of the cell-electrode interface for high-density microelectrode arrays

Cited by 32 publications

References 11 publications

Electrical modeling of the cell–electrode interface for recording neural activity from high-density microelectrode arrays

Electrical modeling of the cell–electrode interface for recording neural activity from high-density microelectrode arrays

A cell-electrode interface noise model for high-density microelectrode arrays

Analytical and Numerical Modeling Methods for Electrochemical Impedance Analysis of Single Cells on Coplanar Electrodes

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