An efficient vanillinyl Schiff base as a turn on fluorescent probe for zinc(ii) and cell imaging

Abstract

Vanillinyl Schiff base (H 2 L), a nontoxic probe and a fluorescent sensor to Zn 2+ , LOD 0.018 µM is used for living cell imaging.

Radiative decay channel assessment to understand the sensing mechanism of a fluorescent turn‐on Al3+ chemosensor

“…[1,6,21] These systems can be incorporated with a fluorescent fraction depending on the purpose and show a great diversity of applications in many fields of science, especially in the detection of metal ions in living cells using a fluorescence microscope. [1,[22][23][24] To make the synthesis process of fluorescent sensors efficient in terms of working time, consumption of reagents, and data collection, [23,25] conducting a more rational design of the structures with predetermined photophysical properties is a topic that needs to be addressed. In this regard, as the behavior of these sensors depends on the careful tuning of their electronic properties, a viable computational characterization constitutes a very useful tool to obtain insight on the chemical properties and the performance of this type of systems.…”

A Phenyl Thioether‐Based Probe: Zn2+ Ion Sensor, Structure Determination and Live Cell Imaging†

“…Herein we report, a diformyl thioether based fluorescent chemosensor, H 2 ‐SAP , prepared by simple Schiff base condensation procedure ( Scheme S1 ) which displays selective fluorescence sensitivity towards Zn 2+ by chelation enhancement fluorescence effect (CHEF) process in presence of large number of ions and could identify Zn 2+ in nM level, much lower than so far reported results . The composition of the complex formed between Zn 2+ and H 2 ‐SAP has been supported by spectroscopic data (Mass, Job's plot) and single crystal X‐ray crystallography.…”

“…have successfully been used. Our group is also engaged in the design of vanillinyl thioether Schiff base, diformyl thioether Schiff base …”

Effect of ‐OMe Substituent on Salicylaldehyde Schiff Base to Influence the Zn2+ Sensitivity and the Cancer Cell Line Imaging

“…However, no significant interference is seen ( Figure S15 ) except for Cu 2+ and Fe 3+ ion due paramagnetic quenching of Fe 3+ (d 5 )/ Cu 2+ (d 9 ). The limit of detection (LOD) for Zn 2+ has been calculated for all these sensors and the value lays from 2.2 to 12.3 nM ( Figure S16 ) (using 3σ method) which is far below the WHO recommended value of Zn 2+ in drinking water (76 μM) and are also lower than some reported Schiff base derivatives of Zn 2+ ion sensor ( Table S1 ) . The binding constant also calculated from Benesi–Hildebrand equation ([(F max ‐ F 0 )/(F ‐F 0 )] vs. 1/[ Zn 2+ ]) and the value fall in the range from 3.3 to 7.06 ×10 4 M −1 ( Figure S17 ).…”