An Efficient Route towards Quinazolinone Derivatives via I2/DMSO-Promoted Oxidative Decarboxylation of α-Amino Acids and Subsequent Oxidative Annulation Reaction

Abstract

An efficient and straightforward strategy was revealed to synthesize a wide range of quinazolinone derivatives from commercially inexpensive 2-aminobenzamide and various amino acids via molecular iodine-promoted oxidative decarboxylation of α-amino acid followed by oxidative cyclization reaction. Operational simplicity, consistent yield, functional group tolerance and sustainability are the other noteworthy features of the reaction. A large number of quinazolinone derivatives were conveniently prepared employing the current strategy. The synthesis of other related heteroarenes such as benzoxazole and benzothiazole derivatives following the same reaction condition broadens the scope of the method.