An ecological approach to identify distinct neural correlates of disinhibition in frontotemporal dementia

Tanguy, Delphine; Batrancourt, Bénédicte; Estudillo-Romero, Alfonso; Baxter, Jamie; Ber, Isabelle Le; Bouzigues, Arabella; Godefroy, Valérie; Funkiewiez, Aurélie; Chamayou, Céline; Volle, Emmanuelle; Rametti‐Lacroux, Armelle; Morandi, Xavier; Jannin, Pierre; Lévy, Richard; Migliaccio, Raffaella

doi:10.1016/j.nicl.2022.103079

Cited by 5 publications

(6 citation statements)

References 105 publications

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“… 15 found disinhibition was associated with reduced cortical thickness in the right insula and parahippocampal gyrus. They (and others 47 ) also found that disinhibition was associated with reduced integrity of the uncinate fasciculus, which connects the anterior temporal lobe to orbitofrontal cortex. These studies, together with the results presented here, call into question the conceptualization of disinhibition as a ‘prefrontal’ syndrome.…”

Section: Discussionmentioning

confidence: 86%

Disinhibition in dementia related to reduced morphometric similarity of cognitive control network

Jenkins,

Heywood,

Gupta

et al. 2024

Brain Communications

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Disinhibition is one of the most distressing and difficult to treat neuropsychiatric symptoms of dementia. It involves socially inappropriate behaviors, such as hypersexual comments, inappropriate approaching of strangers and excessive jocularity. Disinhibition occurs in multiple dementia syndromes, including behavioral variant frontotemporal dementia, and dementia of the Alzheimer’s type. Morphometric Similarity Networks are a relatively new method for examining brain structure and can be used to calculate measures of network integrity on large scale brain networks and subnetworks such as the salience network and cognitive control network. In a cross-sectional study, we calculated Morphometric Similarity Networks to determine whether disinhibition in behavioral variant frontotemporal dementia (n = 75) and dementia of the Alzheimer’s type (n = 111) was associated with reduced integrity of these networks independent of diagnosis. We found that presence of disinhibition, measured by the Neuropsychiatric Inventory Questionnaire, was associated with reduced global efficiency of the cognitive control network in both dementia of the Alzheimer’s type and behavioral variant frontotemporal dementia. Future research should replicate this transdiagnostic finding in other dementia diagnoses and imaging modalities, and investigate the potential for intervention at the level of the cognitive control network to target disinhibition.

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Section: Discussionmentioning

confidence: 86%

Disinhibition in dementia related to reduced morphometric similarity of cognitive control network

Jenkins,

Heywood,

Gupta

et al. 2024

Brain Communications

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“…While we found a consistent association between disinhibition and hippocampal volume, the direction of associations was different. Disinhibition has been mostly studied in frontotemporal dementia and has been shown to be associated with atrophy in the frontal, temporal and limbic brain cortices 44,45 . Furthermore, research suggests that heightened doses of dopamine agonists are associated with an elevated risk of exacerbating disinhibition in individuals diagnosed with PD 46 …”

Section: Resultsmentioning

confidence: 99%

“…Disinhibition has been mostly studied in frontotemporal dementia and has been shown to be associated with atrophy in the frontal, temporal and limbic brain cortices. 44,45 Furthermore, research suggests that heightened doses of dopamine agonists are associated with an elevated risk of exacerbating disinhibition in individuals diagnosed with PD. 46 In addition, at baseline NPI apathy scores were negatively associated with cortical thickness of the bilateral superior temporal, left rostral middle frontal and right insular regions.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease: A cross sectional and longitudinal study

Rashidi‐Ranjbar,

Churchill,

Black

et al. 2024

Int J Geriat Psychiatry

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ObjectivesNeuropsychiatric symptoms (NPS) increase risk of developing dementia and are linked to various neurodegenerative conditions, including mild cognitive impairment (MCI due to Alzheimer's disease [AD]), cerebrovascular disease (CVD), and Parkinson's disease (PD). We explored the structural neural correlates of NPS cross‐sectionally and longitudinally across various neurodegenerative diagnoses.MethodsThe study included individuals with MCI due to AD, (n = 74), CVD (n = 143), and PD (n = 137) at baseline, and at 2‐years follow‐up (MCI due to AD, n = 37, CVD n = 103, and PD n = 84). We assessed the severity of NPS using the Neuropsychiatric Inventory Questionnaire. For brain structure we included cortical thickness and subcortical volume of predefined regions of interest associated with corticolimbic and frontal‐executive circuits.ResultsCross‐sectional analysis revealed significant negative correlations between appetite with both circuits in the MCI and CVD groups, while apathy was associated with these circuits in both the MCI and PD groups. Longitudinally, changes in apathy scores in the MCI group were negatively linked to the changes of the frontal‐executive circuit. In the CVD group, changes in agitation and nighttime behavior were negatively associated with the corticolimbic and frontal‐executive circuits, respectively. In the PD group, changes in disinhibition and apathy were positively associated with the corticolimbic and frontal‐executive circuits, respectively.ConclusionsThe observed correlations suggest that underlying pathological changes in the brain may contribute to alterations in neural activity associated with MBI. Notably, the difference between cross‐sectional and longitudinal results indicates the necessity of conducting longitudinal studies for reproducible findings and drawing robust inferences.

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“…In our study, we found orbital frontal gyrus contributes to both apathy and disinhibition. Apathy and disinhibition were the main behavior symptoms in bvFTD of which the neuroanatomical correlates were widely investigated and demonstrated the significant contributions of the prefrontal cortex ( Farb et al, 2013 ; Godefroy et al, 2022 ; Sheelakumari et al, 2020 ; Tanguy et al, 2022 ; Zhou et al, 2021 ). More specifically, the orbital frontal gyrus was one of the significant brain regions in the frontal-temporal-limbic circuit discovered in previous studies that contribute to apathy using other image modalities ( Godefroy et al, 2022 ; Valotassiou et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…More specifically, the orbital frontal gyrus was one of the significant brain regions in the frontal-temporal-limbic circuit discovered in previous studies that contribute to apathy using other image modalities ( Godefroy et al, 2022 ; Valotassiou et al, 2022 ). And it is well-acknowledged that orbital frontal gyrus is linked to impulsive and disinhibition behavior ( Migliaccio et al, 2020 ; Pattij and Vanderschuren, 2020 ; Tanguy et al, 2022 ), imbalanced activity in the orbitofrontal cortex and nucleus accumbens was known to disrupt behavior inhibition ( Meyer and Bucci, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia

Chu

Jiang

liu

et al. 2023

Neurobiology of Aging

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An ecological approach to identify distinct neural correlates of disinhibition in frontotemporal dementia

Cited by 5 publications

References 105 publications

Disinhibition in dementia related to reduced morphometric similarity of cognitive control network

Disinhibition in dementia related to reduced morphometric similarity of cognitive control network

Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease: A cross sectional and longitudinal study

Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia

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