2022
DOI: 10.3389/fonc.2022.977119
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Abstract: Adult acute lymphoblastic leukemia (ALL) is heterogeneous both biologically and clinically. The outcomes of ALL have been improved with the application of children-like regimens and novel agents including immune therapy in young adults. The refractory to therapy and relapse of ALL have occurred in most adult cases. Factors affecting the prognosis of ALL include age and white blood cell (WBC) count at diagnosis. The clinical implications of genetic biomarkers, including chromosome translocation and gene mutatio… Show more

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Cited by 3 publications
(1 citation statement)
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“…In addition, they have been mechanistically associated with chemoresistance and are enriched at relapse 4,[8][9][10][11][12] . CREBBP mutations have also been described as an adverse prognostic factor in ALL, acute myeloid leukaemia (AML) and follicular lymphoma [13][14][15] . CREBBP is a large protein with histone acetyltransferase (HAT) enzymatic activity alongside protein scaffolding function mediated through multiple protein-protein interaction domains, including a bromodomain responsible for binding acetylated lysine residues.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, they have been mechanistically associated with chemoresistance and are enriched at relapse 4,[8][9][10][11][12] . CREBBP mutations have also been described as an adverse prognostic factor in ALL, acute myeloid leukaemia (AML) and follicular lymphoma [13][14][15] . CREBBP is a large protein with histone acetyltransferase (HAT) enzymatic activity alongside protein scaffolding function mediated through multiple protein-protein interaction domains, including a bromodomain responsible for binding acetylated lysine residues.…”
Section: Introductionmentioning
confidence: 99%