An Easy and Useful Noninvasive Score Based on α-1-acid Glycoprotein and C-Reactive Protein for Diagnosis of Patients with Hepatocellular Carcinoma Associated with Hepatitis C Virus Infection

Omran, Mohamed M.; Emran, Tarek M.; Kosari, Farid; El‐Taweel, F. M. A.; Omar, Mona A.; Bazeed, Fagr B.

doi:10.1080/15321819.2015.1132229

Cited by 12 publications

(8 citation statements)

References 43 publications

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“…Eighteen articles that met the inclusion criteria of our study conducted on the relationship between hepatitis B and hepatitis C and CRP were included in the study. Eleven studies were associated with hepatitis B (2, 7, 15-23) and seven were associated with hepatitis C (1,(9)(10)(11)(12)(13)(14). Table 1 and summarize the pooled mean level, lower limit, upper limit, I 2 , and P value of CRP associated with hepatitis B and hepatitis C, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…It is used to determine the progression and development of the disease inflammatory markers. CRP has been shown to be significantly altered in viral hepatitis (1,2,7,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Studies freely accessible in PubMed or ScienceDirect on hepatitis patients between January 1, 2015, and December 31, 2019, were reviewed that are displayed in Figures 1A and B and 2A and B analyzed by the random-effects model.…”

Section: Selection Of Test Parametersmentioning

confidence: 99%

“…(1), Tatar et al (14), Swanson et al (13), Faillaci et al (12), Goncalvesa et al (10), and Omran et al (9) showed the CRP levels within normal range; however, Barakat et al (11) reported an increase in CRP levels in hepatitis C patients.…”

Section: Random-effects Reml Modelmentioning

confidence: 99%

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CRP Levels in Viral Hepatitis: A Meta-Analysis Study

2020

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Context: Viral hepatitis is a common infectious disorder with a high degree of mortality. The host immunological feedback to the hepatitis virus is dim and unable to down-regulate and clear infection. C-reactive protein (CRP), an acute phase reactant synthesized by hepatocytes in response to inflammatory reactions, facilitates apoptosis and phagocytosis. An effort has been made in the current meta-analysis study to elucidate the relationship between CRP and hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Methods: Eighteen published research articles on CRP levels of viral hepatitis patients were included in this study. A random-effects model was used to calculate the pooled mean level for CRP. Results: The pooled mean level of CRP hepatitis B and hepatitis C was 6.93 mg/L (95% CI: 3.04 - 10.81) and 2.31 mg/L (95% CI: 1.06 - 3.55), respectively. A high degree of variance was observed among the studies, with the I2 more than 90%. Conclusions: The pooled mean level of CRP was within the normal range in patients with hepatitis C; however, it was high in patients with hepatitis B. The pooled mean CRP level reported in this study can be useful to determine the level of liver damage in patients with viral hepatitis.

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Section: Resultsmentioning

confidence: 99%

Section: Selection Of Test Parametersmentioning

confidence: 99%

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CRP Levels in Viral Hepatitis: A Meta-Analysis Study

2020

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“…The combination of AFP and Desgamma-carboxyprothrombin yields an AUC of 0.846 [30]. Omran et al reported that the combination of acid glycoprotein, albumin, C reactive protein, and AFP has an AUC of 0.92 and a sensitivity of 85% [31]. According to Attallah et al, combining cytokeratin-1 and nuclear protein-52 with AFP provides an AUC, sensitivity, and specificity of 0.90, 80%, and 92%, respectively, for identifying HCC [32].…”

Section: Discussionmentioning

confidence: 99%

A novel model based on interleukin 6 and insulin-like growth factor II for detection of hepatocellular carcinoma associated with hepatitis C virus

Omran

Mahlab

Emran

et al. 2021

Journal of Genetic Engineering and Biotechnology

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Background The coexistence of cirrhosis complicates the early detection of hepatocellular carcinoma (HCC). Thus, novel biomarkers for HCC early detection are needed urgently. Traditionally, HCC detection is carried out by evaluating alpha-fetoprotein (AFP) levels combined with imaging techniques. This work aimed to assess interleukin (IL-6) and insulin-like growth factor 2 (IGF 2) as possible HCC markers in comparison to AFP in patients with and without HCC. Results ROC analysis showed that IGF2 had the highest area under the curve (AUC) for discriminating HCC from liver cirrhosis (0.86), followed by IL6 (0.82), AFP (0.72), and platelet count (0.6). A four-marker model was developed and discriminated HCC from liver cirrhosis with an AUC of 0.97. The best cut-off was 1.28, at which sensitivity and specificity were 90% and 85%, respectively. For small tumor (< 2 cm), the model had an AUC of 0.95 compared to AFP (0.72). Also, the model achieved perfect performance with AUC of 0.93, 0.94, and 0.95 for BCLC (0-A), CLIP (0-1), and Okuda (stage I), respectively, compared to AFP (AUC of 0.71, 0.69, and 0.67, respectively). Conclusions The four markers may serve as a diagnostic model for HCC early stages and help overcome AFP poor sensitivity.

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“…Because evidence has established that ORM is associated with carcinogenesis and behavior in many organs, changes in the ORM serum level in HCC have been investigated as diagnostic markers. The results of many studies have indicated that the ORM level is increased in patients with HCC and is significantly higher than that in patients with chronic hepatitis and cirrhosis[ 34 - 37 ]. ORM has also been shown to improve HCC diagnostic performance when combined with other markers, such as des-g-carboxy prothrombin (DCP)[ 38 ].…”

Section: Orm In Liver Tumorsmentioning

confidence: 99%

Orosomucoid in liver diseases

Elpek¹

2021

WJG

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In this editorial, the roles of orosomucoid (ORM) in the diagnoses and follow-up assessments of both nonneoplastic diseases and liver tumors are discussed with respect to the publication by Zhu et al presented in the previous issue of World Journal of Gastroenterology (2020; 26(8): 840-817). ORM, or alpha-1 acid glycoprotein (AGP), is an acute-phase protein that constitutes 1% to 3% of plasma proteins in humans and is mainly synthesized in the liver. ORM exists in serum as two variants: ORM1 and ORM2. Although the variants share 89.6% sequence identity and have similar biological properties, ORM1 constitutes the main component of serum ORM. An interesting feature of ORM is that its biological effects differ according to variations in glycosylation patterns. This variable feature makes ORM an attractive target for diagnosing and monitoring many diseases, including those of the liver. Recent findings suggest that a sharp decrease in ORM level is an important marker for HBV-associated acute liver failure (ALF), and ORM1 plays an important role in liver regeneration. In viral hepatitis, increases in both ORM and its fucosylated forms and the correlation of these increases with fibrosis progression suggest that this glycoprotein can be used with other markers as a noninvasive method in the follow-up assessment of diseases. In addition, similar findings regarding the level of the asialylated form of ORM, called asialo-AGP (AsAGP), have been reported in a follow-up assessment of fibrosis in chronic liver disease. An increase in ORM in serum has also been shown to improve hepatocellular carcinoma (HCC) diagnosis performance when combined with other markers. In addition, determination of the ORM level has been useful in the diagnosis of HCC with AFP concentrations less than 500 ng/mL. For monitoring patients with AFP-negative HCC, a unique trifucosylated tetra-antennary glycan of ORM may also be used as a new potential marker. The fact that there are very few studies investigating the expression of this glycoprotein and its variants in liver tissues constitutes a potential limitation, especially in terms of revealing all the effects of ORM on carcinogenesis and tumor behavior. Current findings indicate that ORM2 expression is decreased in tumors, and this is related to the aggressive course of the disease. Parallel to this finding, in HCC cell lines, ORM2 decreases HCC cell migration and invasion, supporting reports of its tumor suppressor role. In conclusion, the levels of ORM and its different glycosylated variants are promising additional biomarkers for identifying ALF, for monitoring fibrosis in viral hepatitis, and for diagnosing early HCC. Although there is evidence that the loss of ORM2 expression in HCC is associated with poor prognosis, further studies are needed to support these findings. Additionally, investigations of ORM expression in borderline dysplastic nodules and hepatocellular adenomas, which pose diagnostic problems in the differential diagnosis of HC...

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An Easy and Useful Noninvasive Score Based on α-1-acid Glycoprotein and C-Reactive Protein for Diagnosis of Patients with Hepatocellular Carcinoma Associated with Hepatitis C Virus Infection

Cited by 12 publications

References 43 publications

CRP Levels in Viral Hepatitis: A Meta-Analysis Study

CRP Levels in Viral Hepatitis: A Meta-Analysis Study

A novel model based on interleukin 6 and insulin-like growth factor II for detection of hepatocellular carcinoma associated with hepatitis C virus

Orosomucoid in liver diseases

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