Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.10.055 View full text
Sonja Peters, Erwin Kaal, Iwan Horsting, Hans-Gerd Janssen

Abstract: A new method is presented for the analysis of phenolic acids in plasma based on ion-pairing 'Micro-extraction in packed sorbent' (MEPS) coupled on-line to in-liner derivatisation-gas chromatography-mass spectrometry (GC-MS). The ion-pairing reagent served a dual purpose. It was used both to improve extraction yields of the more polar analytes and as the methyl donor in the automated in-liner derivatisation method. In this way, a fully automated procedure for the extraction, derivatisation and injection of a wi…

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