An automated detection of influenza virus based on 3-D magnetophoretic separation and magnetic label

Hong, Shao-Li; Zhang, Nangang; Qin, Li; Tang, Man; Ai, Zhao; Chen, Aiju; Wang, Shuibing; Liu, Kan

doi:10.1039/d0an01854f

Cited by 9 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, because biological samples have few magnetic background signals which can be ignored, the magnetic detection method has high specificity, sensitivity, and signal-to-noise ratio [199]. Hong et al constructed an automated detection device for H7N9 influenza virus hemagglutinin, assisted by three-dimensional (3-D) magnetophoretic separation and magnetic label [200]. As shown in Figure 7c, a 3-D microchannel network with two-level channels was generated with multilayer glass slides under a magnetic field perpendicular to the microchannel.…”

Section: Magnetic Detectionmentioning

confidence: 99%

See 1 more Smart Citation

Public-Health-Driven Microfluidic Technologies: From Separation to Detection

Zhang

Wang

et al. 2021

Micromachines

View full text Add to dashboard Cite

Separation and detection are ubiquitous in our daily life and they are two of the most important steps toward practical biomedical diagnostics and industrial applications. A deep understanding of working principles and examples of separation and detection enables a plethora of applications from blood test and air/water quality monitoring to food safety and biosecurity; none of which are irrelevant to public health. Microfluidics can separate and detect various particles/aerosols as well as cells/viruses in a cost-effective and easy-to-operate manner. There are a number of papers reviewing microfluidic separation and detection, but to the best of our knowledge, the two topics are normally reviewed separately. In fact, these two themes are closely related with each other from the perspectives of public health: understanding separation or sorting technique will lead to the development of new detection methods, thereby providing new paths to guide the separation routes. Therefore, the purpose of this review paper is two-fold: reporting the latest developments in the application of microfluidics for separation and outlining the emerging research in microfluidic detection. The dominating microfluidics-based passive separation methods and detection methods are discussed, along with the future perspectives and challenges being discussed. Our work inspires novel development of separation and detection methods for the benefits of public health.

show abstract

Section: Magnetic Detectionmentioning

confidence: 99%

“…(c) Schematic of the detection device based on the 3-D magnetophoretic separation and magnetic label. The figure has been reproduced with permission from the American Chemical Society[200].…”

mentioning

confidence: 99%

Public-Health-Driven Microfluidic Technologies: From Separation to Detection

Zhang

Wang

et al. 2021

Micromachines

View full text Add to dashboard Cite

show abstract

“…The inside of the glass capillary channel was also functionalized with antibodies to form a sandwich assay. [236] The magnetic particles can separate the target biomolecule (DNA, protein, RNA, cells, pathogens) from the complex medium such blood or serum and then the captured target biomolecule can be suspended in a friendly buffer which can be conveniently used with microfluidics or microstructures. [314] Various magnetic particles are commercially available and can be purchased easily.…”

Section: Magnetic Separationmentioning

confidence: 99%

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Ebrahimi,

Icoz,

Didarian

et al. 2023

Adv Materials Inter

View full text Add to dashboard Cite

Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab‐on‐a‐chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic‐based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab‐on‐a‐chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques.

show abstract

“…217 Additionally, nanoparticles with magnetic characteristics can also be used to enrich viral assays and enable ultrasensitive detection. 218 Some inorganic nanomaterials show exceptional fluorescent properties and can be used for tracking single virus particles. 96 3.1 Virus sensing 3.1.1 Gold nanoparticles.…”

Section: Inorganic Nanomaterials In Virus Sensing and Trackingmentioning

confidence: 99%