An attempt to produce choledochal cyst in puppies

Kato, Taichi; Asakura, Yoshihiro; Kasai, Morio

doi:10.1016/s0022-3468(74)80016-3

Cited by 18 publications

(11 citation statements)

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“…wall of the biliary duct. From the histological findings of the wall of choledochal cysts in patients as well as in experimental animals, digestion of elastic fibers by elastase seems to be a principal cause of weakness of the wall of the common bile duct (Kato 1972;Kato et al 1974). It is obscure why stenotic change followed by severer productive cholangitis is formed particularly in the lower portion of common bile duct in this experiment.…”

Section: Resultsmentioning

confidence: 72%

“…From our previous study of experimental choledochal cyst, however, distal obstruction and structural weakness of the common bile duct appeared to play a major role for its occurrence (Kato 1972;Kato et al 1974).…”

mentioning

confidence: 99%

“…Recently, the reflux of pancreatic juice into the biliary duct due to anomalous arrangement of the pancreatico-biliary ducts has been considered as one of the contributing factors (Babitt 1969;Babitt et al 1973; Kato et al 1974). This anomaly consists of a long common channel sometimes associated with right angle between common and pancreatic ducts.…”

mentioning

confidence: 99%

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Etiology of congenital choledochal cyst.

Kato

Hebiguchi

Kasai³

1980

Tohoku J. Exp. Med.

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Section: Resultsmentioning

confidence: 72%

mentioning

confidence: 99%

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Etiology of congenital choledochal cyst.

Kato

Hebiguchi

Kasai³

1980

Tohoku J. Exp. Med.

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“…Various animal models of induced pancreatobiliary reflux have been reported [20][21][22][23]. Most show chronic biliary mucosal inflammation and, if left long enough, mucosal hyperplasia and stone formation [23].…”

Section: Discussionmentioning

confidence: 99%

Under pressure: choledochal malformation manometry

Davenport¹,

Basu²

2005

Journal of Pediatric Surgery

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“…Various experimental models were proposed (4,18), but they were intended only to produce cystic dilatation of the choledochus (4,18). Among these, the reflux of pancreatic juice was planned by Mizuno (12), Komi(8) andKato (5).…”

Section: Discussionmentioning

confidence: 99%

The Production of Anomalous Pancreaticobiliary Ductal Union in Canine Models

Ohkawa¹,

Sawaguchi²,

Yamazaki³

et al. 1981

Eur J Pediatr Surg

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For the purpose of resolving the mechanism of the ill-effect of refluxed pancreatic juice, due to the anomalous pancreaticobiliary ductal union, canine models were produced. Mongrel adult dogs and puppies were used. Pancreatico-cholecystostomy was performed on 5 adult dogs and 5 puppies. Pancreatico-choledochostomy was performed on 10 adult dogs and 5 puppies. In both procedures, the cylindrical dilatation of the choledochus resulted. The pathological changes in the choledochus were very similar to the cylindrical choledochal dilatation in the human. Elastic fibers diminished universally and in some cases they vanished completely. The changes in the papilla of the bile duct were very slight. There were no cases with hardened papilla. The pathological changes were greater in the pancreatico-cholecystostomy. Enzymatic analysis of pancreatic juice in bile was very important in explaining the etiology. Amylase was proven to be very high throughout the cases, over 10,000 IU/1 by enzymatic assay. Trypsin and elastase were proven to be activated in pancreatico-cholecystostomy, naturally assuming the existence of enterokinase. They were aso proved to be activated in the pancreatico-choledochostomy, without the existence of enterokinase. Though the mechanism was not clear, the activated proteases were the actual cause of the ill-effect in this anomaly. Thus we have succeeded in producing the ideal animal models of the reflux of pancreatic juice into the bile duct in adult dogs and puppies.

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An attempt to produce choledochal cyst in puppies

Cited by 18 publications

References 0 publications

Etiology of congenital choledochal cyst.

Etiology of congenital choledochal cyst.

Under pressure: choledochal malformation manometry

The Production of Anomalous Pancreaticobiliary Ductal Union in Canine Models

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