An Asian–Native American paternal lineage identified by <i>RPS4Y</i> resequencing and by microsatellite haplotyping

Bergen, Andrew W.; Wang, C.-Y.; Tsai, J.; Jefferson, Kimberly K.; Dey, Cody J.; Smith, Kirby D.; Park, S.-C.; Tsai, Shun-Hung; Goldman, David

doi:10.1046/j.1469-1809.1999.6310063.x

Cited by 78 publications

(58 citation statements)

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“…Furthermore, a handful of C-M217 Y chromosomes without the P39 marker were found in southeast Alaska and Colombia, South America (23,27,46,47). The spread of C-P39 involved mostly Athapaskan speakers and was associated with a second wave of expansion, which is the same as Q1a6 for Eskimoan speakers.…”

Section: Discussionmentioning

confidence: 83%

Y-chromosome analysis reveals genetic divergence and new founding native lineages in Athapaskan- and Eskimoan-speaking populations

Dulik

Owings²,

Gaieski³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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For decades, the peopling of the Americas has been explored through the analysis of uniparentally inherited genetic systems in Native American populations and the comparison of these genetic data with current linguistic groupings. In northern North America, two language families predominate: Eskimo-Aleut and Na-Dene. Although the genetic evidence from nuclear and mtDNA loci suggest that speakers of these language families share a distinct biological origin, this model has not been examined using data from paternally inherited Y chromosomes. To test this hypothesis and elucidate the migration histories of Eskimoan- and Athapaskan-speaking populations, we analyzed Y-chromosomal data from Inuvialuit, Gwich’in, and Tłįchǫ populations living in the Northwest Territories of Canada. Over 100 biallelic markers and 19 chromosome short tandem repeats (STRs) were genotyped to produce a high-resolution dataset of Y chromosomes from these groups. Among these markers is an SNP discovered in the Inuvialuit that differentiates them from other Aboriginal and Native American populations. The data suggest that Canadian Eskimoan- and Athapaskan-speaking populations are genetically distinct from one another and that the formation of these groups was the result of two population expansions that occurred after the initial movement of people into the Americas. In addition, the population history of Athapaskan speakers is complex, with the Tłįchǫ being distinct from other Athapaskan groups. The high-resolution biallelic data also make clear that Y-chromosomal diversity among the first Native Americans was greater than previously recognized.

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Section: Discussionmentioning

confidence: 83%

Y-chromosome analysis reveals genetic divergence and new founding native lineages in Athapaskan- and Eskimoan-speaking populations

Dulik

Owings²,

Gaieski³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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“…The most frequent haplotype was M5 (14.7%; with sequence motif; 73-750-16129-16290-16304) and M3 (5.9%; 16223-16311), followed by A4 (3.4%; 16129-16223-16290-16362) and R21 (3.2%; 152-16223-16362, 16519) [15]- [18] most common haplogroup frequencies shown in Table 1.…”

Section: Haplogroup Structure and Most Common Haplotypesmentioning

confidence: 99%

Mitochondrial DNA Control Region Variation from Bangladesh: Sequence Analysis for the Establishment of a Forensic Database

Sultana¹,

Tuli²,

Begum³

et al. 2014

FMAR

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Mitochondrial DNA sequences of the entire control region and three coding regions were analyzed in 108 unrelated individuals from three regions of Bangladesh. Sequence evaluation was performed with validated primers and combined sequence comparison led to the identification of 14 different haplotypes characterized by 37 variable polymorphic sites. The Bangladeshi sequences exhibited high variations and low random match probability, indicating for forensic application. The mean pairwise difference between individual was 9.698 ± 1.8658 nucleotides (95% CI 9.67 -9.69), compared to a mean pairwise difference of 9.890 ± 4.189 nucleotides reported from Northeast Asia and suggested significant differences in the mtDNA composition of the various populations. The sequence diversity of 108 Bangladeshi Bengali samples (n = 216 chromosomes) was estimated to be 0.8475 ± 0.13406. This study first time reports that the comparison of closely related mtDNA sequences can be very useful for improving mtDNA database quality, as well as provide haplotype information for forensic study in mainstream population of Bangladesh.

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“…To reveal the patrilineal population dynamics, we analysed six SNPs from the nonrecombining portion of the Y chromosome (NRY-DNA) characterising the NRY-haplogroups C * (Underhill et al, 1997;Bergen et al, 1999;Ruiz-Linares et al, 1999;Underhill et al, 2001;Seielstad et al, 2003;Karafet et al, 2008) following the nomenclature of the Y Chromosome Consortium (2002). The haplogroup Q1a3a…”

Section: Y-chromosomal Haplogroup Analysismentioning

confidence: 99%

Diachronic Investigations of Mitochondrial and Y-Chromosomal Genetic Markers in Pre-Columbian Andean Highlanders from South Peru

Fehren‐Schmitz¹,

Warnberg²,

Reindel

et al. 2010

Annals of Human Genetics

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SummaryThis study examines the reciprocal effects of cultural evolution, and population dynamics in pre-Columbian southern Peru by the analysis of DNA from pre-Columbian populations that lived in the fringe area between the Andean highlands and the Pacific coast. The main objective is to reveal whether the transition from the Middle Horizon (MH: 650-1000 AD) to the Late Intermediate Period (LIP: 1000-1400 AD) was accompanied or influenced by population dynamic processes. Tooth samples from 90 individuals from several archaeological sites, dating to the MH and LIP, in the research area were collected to analyse mitochodrial, and Y-chromosomal genetic markers. Coding region polymorphisms were successfully analysed and replicated for 72 individuals, as were control region sequences for 65 individuals and Ychromosomal single nucleotide polymorphisms (SNPs) for 19 individuals, and these were compared to a large set of ancient and modern indigenous South American populations. The diachronic comparison of the upper valley samples from both time periods reveals no genetic discontinuities accompanying the cultural dynamic processes. A high genetic affinity for other ancient and modern highland populations can be observed, suggesting genetic continuity in the Andean highlands at the latest from the MH. A significant matrilineal differentiation to ancient Peruvian coastal populations can be observed suggesting a differential population history.

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An Asian–Native American paternal lineage identified by RPS4Y resequencing and by microsatellite haplotyping

Cited by 78 publications

References 0 publications

Y-chromosome analysis reveals genetic divergence and new founding native lineages in Athapaskan- and Eskimoan-speaking populations

Y-chromosome analysis reveals genetic divergence and new founding native lineages in Athapaskan- and Eskimoan-speaking populations

Mitochondrial DNA Control Region Variation from Bangladesh: Sequence Analysis for the Establishment of a Forensic Database

Diachronic Investigations of Mitochondrial and Y-Chromosomal Genetic Markers in Pre-Columbian Andean Highlanders from South Peru

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