An appraisal on synthetic and pharmaceutical perspectives of quinoxaline 1,<scp>4‐di‐<i>N</i></scp>‐oxide scaffold

Agrawal, Neetu; Bhardwaj, Aditya

doi:10.1111/cbdd.14094

Cited by 8 publications

(2 citation statements)

References 91 publications

(85 reference statements)

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“…However, currently, a more efficient method for quinoxaline 1,4-dioxide derivatives has become the heterocyclization of benzo with enols or enamines by the Beirut reaction. Methods for the synthesis and biological activity of quinoxaline 1,4-dioxides have been previously discussed in several papers [26][27][28][29][30][31][32][33][34][35][36]. However, the reviews published in the last twenty years have primarily focused on the biological aspects of quinoxaline 1,4-dioxides, providing limited consideration of their chemical properties and structureactivity relationships.…”

Section: Methods Of the Synthesis Of Quinoxaline 14-dioxidesmentioning

confidence: 99%

“…Methods for the synthesis and biological activity of quinoxaline 1,4-dioxides have been previously discussed in several papers [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. However, the reviews published in the last twenty years have primarily focused on the biological aspects of quinoxaline 1,4-dioxides, providing limited consideration of their chemical properties and structure-activity relationships.…”

Section: Introductionmentioning

confidence: 99%

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Quinoxaline 1,4-Dioxides: Advances in Chemistry and Chemotherapeutic Drug Development

Buravchenko,

Shchekotikhin

2023

Pharmaceuticals

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N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse biological properties. The high reactivity and tendency to undergo various rearrangements have piqued the interest of synthetic chemists in heterocycles with N-oxide fragments. Quinoxaline 1,4-dioxides are an example of an important class of heterocyclic N-oxides, whose wide range of biological activity determines the prospects of their practical use in the development of drugs of various pharmaceutical groups. Derivatives from this series have found application in the clinic as antibacterial drugs and are used in agriculture. Quinoxaline 1,4-dioxides present a promising class for the development of new drugs targeting bacterial infections, oncological diseases, malaria, trypanosomiasis, leishmaniasis, and amoebiasis. The review considers the most important methods for the synthesis and key directions in the chemical modification of quinoxaline 1,4-dioxide derivatives, analyzes their biological properties, and evaluates the prospects for the practical application of the most interesting compounds.

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Section: Methods Of the Synthesis Of Quinoxaline 14-dioxidesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quinoxaline 1,4-Dioxides: Advances in Chemistry and Chemotherapeutic Drug Development

Buravchenko,

Shchekotikhin

2023

Pharmaceuticals

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Recent advances on quinoxalines as target‐oriented chemotherapeutic anticancer agents through apoptosis

Nafie,

Kahwash,

Youssef

et al. 2024

Archiv der Pharmazie

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The current review outlines all possible recent synthetic platforms to quinoxaline derivatives and the potent stimulated apoptosis mechanisms targeted by anticancer therapies. The currently reported results disclosed that quinoxaline derivatives had promising anticancer potencies against a wide array of cancer cell lines, better than the reference drugs, through target inhibition. This review summarizes some potent quinoxaline derivatives with their synthesis strategies and their potential activities against various molecular targets. Quinoxalines can be considered an important scaffold for apoptosis inducers in cancer cells through inhibiting some molecular targets, so they can be further developed as target‐oriented chemotherapeutics.

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A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline

2023

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In last few decades, nitrogen‐containing heterocycles have maintained their status as an important core of FDA‐approved drugs and medicinally active compounds. Quinoxaline is one such class of nitrogen‐containing scaffold that has become a subject of extensive research as it possess a plethora of biological activities. Molecular hybridization is a versatile and rational approach to drug design that involves the combination of two bioactive molecules possessing distinct intrinsic activity into a single scaffold for enhancing their therapeutic potential. In view of this, the advancement and potential of quinoxaline hybrids bearing thiazole, triazole, oxadiazole, pyrrolizines, pyrazole, etc. have attracted the keen attention of researchers to explore their therapeutic ability against different biological targets. The present review includes the research in the recent years (2018–2023) and addresses the graceful advancements in the studies related to quinoxaline‐based small molecules including their synthetic routes, biological activities and structure‐activity relationships. We anticipate that this review article will provide comprehensive knowledge of pharmacological importance of quinoxaline analogues and will fulfill the need of scientific community in designing and developing efficacious novel molecules.

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An appraisal on synthetic and pharmaceutical perspectives of quinoxaline 1,4‐di‐N‐oxide scaffold

Cited by 8 publications

References 91 publications

Quinoxaline 1,4-Dioxides: Advances in Chemistry and Chemotherapeutic Drug Development

Quinoxaline 1,4-Dioxides: Advances in Chemistry and Chemotherapeutic Drug Development

Recent advances on quinoxalines as target‐oriented chemotherapeutic anticancer agents through apoptosis

A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline

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