An Appraisal of Current Systemic Chemotherapy for Psoriasis

Psoriasis and its treatment.

“…Azathioprine, azaribine, mycophenolic acid, nitrogen mustard, and other antimitotic drugs have also been used for psoriasis with varying success and enthusiasm. 46 In Europe retinoic acid derivatives-the oral retinoidshave been available for some years but in Britain are still available only for clinical trials, though a product licence is expected shortly. They promise well.53 5 Undoubtedly effective, they do, nevertheless, cause side effects, especially on the skin and mucous membranes, but they also include the possibility of teratogenicity.…”

A Novel Non-polyglutamable Anti-folate, MX-68, Inhibits the Induction of Experimental Autoimmune Uveitis in Rats

“…Methotrexate is effective in the treatment of patients with autoimmune diseases such as rheumatoid arthritis (Kremer and Phelps, 1992 ;Bannwarth et al, 1994), psoriasis (Farber, Pearlman and Abel, 1976), polymyositis and uveitis (Wong et al, 1965 ;Wong, 1966 ;Shah et al, 1992). Recently, MTX has been commonly used in the treatment of rheumatoid arthritis.…”

Topical corticosteroids and relapses of psoriasis.

“…1965, 70, 753. 3 Schlichter, J, Hellerstein, H K, and Katz, L N, Medicine, 1954, 33, 43. 4Donaldson, R M, et al, British Heart_Journal, 1976, 38, 1223. 5 Loop, F D, et al, Annals of Surgery, 1973, 178, 399.…”