2012
DOI: 10.1038/nature11405
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Abstract: Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic brain architecture. Here we describe the generation and analysis of a transcriptional atlas of the adult human brain, comprising extensive histological analysis and comprehensive microarray profiling of ~900 neuroanatomically precise subdivisions in two individuals. Transcriptional regulation varies enormously by anatomical location, with dif… Show more

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Cited by 2,302 publications
(2,644 citation statements)
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References 32 publications
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“…Despite the cellular heterogeneity inherent in different brain regions, network analytic techniques like weighted gene co-expression network analysis (WGCNA) 10 have revealed biologically meaningful trends in meso-scale sampled transcriptome data that relate to anatomy and brain function. Indeed, previous analysis using WGCNA on the first human brain from this dataset identified co-expression modules that were generally corroborated in the second brain 3 .…”
Section: A Canonical Brain Transcription Co-expression Networksupporting
confidence: 58%
“…Despite the cellular heterogeneity inherent in different brain regions, network analytic techniques like weighted gene co-expression network analysis (WGCNA) 10 have revealed biologically meaningful trends in meso-scale sampled transcriptome data that relate to anatomy and brain function. Indeed, previous analysis using WGCNA on the first human brain from this dataset identified co-expression modules that were generally corroborated in the second brain 3 .…”
Section: A Canonical Brain Transcription Co-expression Networksupporting
confidence: 58%
“…While differential gene expression is most pronounced during prenatal development [39] and between subcortical structures [40], substantial spatial variation has also been described within the adult human cerebral cortex [40][41][42][43].…”
Section: Glossarymentioning
confidence: 99%
“…Following the approach presented in Rizzo et al, 30 we derived the TSPO mRNA mappings from the Allen Human Brain Atlas, made of six healthy human brains, 31 finely sampled with three different probes, and we compared them with the V T estimated with 2TCM and 2TCM-1K. Under the assumption that mRNA expression is predictive of the in vivo protein density of unrelated normal subjects, we evaluated whether the [ 11 C]PBR28 binding description obtained with the two models in competition were consistent with TSPO brain gene profiles.…”
Section: Comparison Of [ 11 C]pbr28 Pet Binding With Brain Mrna Tspomentioning
confidence: 99%