An Analysis of Surgical Treatment Results of Patients With Tympanosclerosis

Mutlu, Fatih Mehmet; İşeri, Mete; Erdoğan, Selvet; Öztürk, Murat; Sarı, Fatih

doi:10.1097/scs.0000000000002152

Cited by 12 publications

(10 citation statements)

References 17 publications

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“…Our findings support the consideration of tympanosclerosis as a middle-age disease with a higher prevalence in females (Mutlu et al 2015;Aslan et al 2010). In addition, our findings are also consistent with more common manifestation of open type tympanosclerosis with perforated tympanic membrane mostly located in the pars tensa , as well as bilateral ear involvement (range from 40% to 60%) indicating the likelihood of a systemic response to promote development of tympanosclerosis (Gibb et al 1994;Bayazit et al 2004;Aslan et al 2010).…”

Section: J Cell Neurosci Oxid Stress 2019; 11: 825 -834supporting

confidence: 87%

The epidemiology of tympanosclerosis in chronic otitis media patients in the Kars region of Turkey: The role of computerized temporal tomography in diagnosis of tympanosclerosis

Kütük¹,

Bora²

2019

Journal of Cellular Neuroscience and Oxidative Stress

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Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease. Areas of particular interest are four topics. They are; A-Ion Channels (Na +-K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)

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Section: J Cell Neurosci Oxid Stress 2019; 11: 825 -834supporting

confidence: 87%

The epidemiology of tympanosclerosis in chronic otitis media patients in the Kars region of Turkey: The role of computerized temporal tomography in diagnosis of tympanosclerosis

Kütük¹,

Bora²

2019

Journal of Cellular Neuroscience and Oxidative Stress

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“…The choice of surgery is believed to be reliable, efficient with long‐lasting hearing results and it is associated with a low incidence of complications 16,19,20 . Ears with less ossicular chain involvement and limited localization of sclerotic plaques have better hearing gain 21 . The first aim of surgery is to repair the perforated drum, knowing that the graft uptake in tympanosclerosis is excellent and similar to tympanoplasty without tympanosclerosis with a success rate of around 90%; irrespective of whether plaques are excised or not 21,22 .…”

Section: Discussionmentioning

confidence: 99%

“…Ears with less ossicular chain involvement and limited localization of sclerotic plaques have better hearing gain 21 . The first aim of surgery is to repair the perforated drum, knowing that the graft uptake in tympanosclerosis is excellent and similar to tympanoplasty without tympanosclerosis with a success rate of around 90%; irrespective of whether plaques are excised or not 21,22 . The removal of the tympanosclerotic plaques from the residual tympanic membrane is not indicated unless it is large and/or joining the tympanic annulus to the manubrium which impairs the TM mobility.…”

Section: Discussionmentioning

confidence: 99%

Reliability of high‐resolution CT scan in diagnosis of ossicular tympanosclerosis

Larem

Altamimi

Aljariri

et al. 2021

Laryngoscope Investig Oto

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Objectives To evaluate the reliability of high‐resolution CT scans (HRCT scans) in the diagnosis of tympanosclerosis and to determine its benefit to predict the post‐surgical hearing outcome based on comparing radiological and surgical findings. Methods A retrospective study at a tertiary institute included 940 ears that underwent tyampanoplasty for chronic suppurative otitis media (CSOM) between January 2013 and March 2017. Preoperative temporal bone HRCT scans were analyzed to check for the prediction of tympanosclerosis and ossicular fixation. Intraoperatively, ossicular chain integrity was checked. Preoperative and postoperative audiometric evaluations using air‐bone gap (ABG) were compared. A postoperative pure‐tone ABG of 20 dB or less was considered as a successful hearing result. Results are compared with historical control groups, the study has been reviewed and approved by the IRB at the medical research center in Hamad Medical Corporation; however, it is a retrospective study so no informed consent was obtained from the patients. Results The study included 940 ears that underwent tympanoplasties due to CSOM, where 238 out of 940 (25.3%) of ears showed tympanosclerosis during tympanoplasty, intraoperatively, tympanosclerosis was localized to the eardrum in 174 of the 238 involved ears (73.1%), A 64 out of 238 (26.9%) of the ears with tympanosclerosis showed ossicular fixation, divided as 45 ears with Incudo‐malleal fixation, 14 ears with stapes fixation, and 5 ears with triple ossicular fixation. HRCT scan of the temporal bone was suggestive of ossicular chain fixation in 79 cases distributed as 55 incudo‐malleal fixations, 19 stapes fixation, and 5 complete ossicular fixations, with a sensitivity of 96.8%, and specificity of 98%. The audiological results were analyzed, with a patient follow‐up after 6 months. Conclusions Our study showed that CT scans when combined with the clinical findings can be an informative guide to otolaryngologists for preoperative evaluation and counseling of tympanosclerosis surgeries.

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“…6 Hence, surgery is by far the most helpful procedure to restore hearing. 7,8 However, for patients with tympanosclerosis, surgery should be performed with caution, because in many cases it is much more complicated than for patients without tympanosclerosis. 9 The calcified plaques which alter the compliance of the tympanic membrane and limit the mobility of the ossicles, need to be removed during the surgery.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Clinical Score for Predicting the Risk of Tympanosclerosis Before Surgery

Dong

Zhou

et al. 2020

Ear Nose Throat J

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Objective: To develop and validate a clinical score to predict the risk of tympanosclerosis before surgery. Methods: A sample of 404 patients who underwent middle ear microsurgery for otitis media was enrolled. These patients were randomly divided into 2 cohorts: the training cohort (n = 243, 60%) and the validation cohort (n = 161, 40%). The preoperative predictors of tympanosclerosis were determined by multivariate logistic regression analysis and implemented using a clinical score tool. The predictive accuracy and discriminative ability of the clinical score were determined by the area under the curve (AUC) and the calibration curve. Results: The multivariate analysis in the training cohort (n = 243, 60%) identified independent factors for tympanosclerosis as the female sex (odds ratio [OR]: 3.83; 95% CI: 1.66-9.37), the frequency-specific air-bone gap at 250 Hz ≥ 45 dB HL (OR: 3.68; 95% CI: 1.68-8.57), aditus ad antrum blockage (OR: 3.29; 95% CI: 1.38-8.43), type I eardrum calcification (OR: 25.37; 95% CI: 8.41-88.91) or type II eardrum calcification (OR: 18.86; 95% CI: 6.89-58.77), and a history of otitis media ≥ 10 years (OR: 4.10; 95% CI: 1.58-11.83), which were all included in the clinical score tool. The AUC of the clinical score for predicting tympanosclerosis was 0.89 (95% CI: 0.85-0.93) in the training cohort and 0.89 (95% CI: 0.84-0.95) in the validation cohort. The calibration curve also showed good agreement between the predicted and observed probability. Conclusions: The clinical score achieved an optimal prediction of tympanosclerosis before surgery. The presence of calcification pearls on the promontorium tympani is a strong predictor of tympanosclerosis with stapes fixation.

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An Analysis of Surgical Treatment Results of Patients With Tympanosclerosis

Abstract: Patients with less impact on ossicular chain and limited localization of sclerotic plaques have better hearing gain. Although surgery is still controversial in tympanosclerosis; it is the most effective treatment till new effective medication is discovered.

Cited by 12 publications

References 17 publications

The epidemiology of tympanosclerosis in chronic otitis media patients in the Kars region of Turkey: The role of computerized temporal tomography in diagnosis of tympanosclerosis

The epidemiology of tympanosclerosis in chronic otitis media patients in the Kars region of Turkey: The role of computerized temporal tomography in diagnosis of tympanosclerosis

Reliability of high‐resolution CT scan in diagnosis of ossicular tympanosclerosis

Development and Validation of a Clinical Score for Predicting the Risk of Tympanosclerosis Before Surgery

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