2002
DOI: 10.1038/sj.bjc.6600155
|View full text |Cite
|
Sign up to set email alerts
|

An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation

Abstract: Tumours of patients with node-positive rectal cancer were studied by immunohistochemistry for p53, BAX and vascular endothelial growth factor expressions. Results were correlated to the relapse rate, the pattern of relapse and the event-free survival after radical surgery and adjuvant chemoradiation. After a median follow-up of 60 months, 39 patients remained disease-free and 40 patients relapsed (18 local relapses and 22 distant metastases). The majority of disease-free patients showed p53 negative and vascul… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
32
0

Year Published

2003
2003
2014
2014

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 42 publications
(32 citation statements)
references
References 42 publications
0
32
0
Order By: Relevance
“…The main features of eligible studies for VEGF are summarized in Table 2 Takahashi et al, 1997;Cascinu et al, 2000;Maeda et al, 2000;Cascinu et al, 2001;Cascinu et al, 2002;Nanni et al, 2002;White et al, 2002;Galizia et al, 2004) for RFS and 10 for OS (n ¼ 1301) (Ishigami et al, 1998;Tokunaga et al, 1998;Lee et al, 2000;Harada et al, 2001;Nanni et al, 2002;White et al, 2002;Kaio et al, 2003b;Khorana et al, 2003;Zheng et al, 2003;Tamura et al, 2004). High VEGF significantly predicted poor RFS (RR ¼ 2.84; 95% CI: 1.95 -4.16; Po0.001) and poor OS (RR ¼ 1.65; 95% CI: 1.27 -2.14; Po0.001).…”
Section: Resultsmentioning
confidence: 99%
“…The main features of eligible studies for VEGF are summarized in Table 2 Takahashi et al, 1997;Cascinu et al, 2000;Maeda et al, 2000;Cascinu et al, 2001;Cascinu et al, 2002;Nanni et al, 2002;White et al, 2002;Galizia et al, 2004) for RFS and 10 for OS (n ¼ 1301) (Ishigami et al, 1998;Tokunaga et al, 1998;Lee et al, 2000;Harada et al, 2001;Nanni et al, 2002;White et al, 2002;Kaio et al, 2003b;Khorana et al, 2003;Zheng et al, 2003;Tamura et al, 2004). High VEGF significantly predicted poor RFS (RR ¼ 2.84; 95% CI: 1.95 -4.16; Po0.001) and poor OS (RR ¼ 1.65; 95% CI: 1.27 -2.14; Po0.001).…”
Section: Resultsmentioning
confidence: 99%
“…In particular, bevacizumab, a humanised monoclonal antibody inhibiting VEGF-A, in combination with standard chemotherapy regimens was beneficial both in terms of response rate and survival as firstand second-line treatment of patients affected by metastatic colorectal cancer. In patients affected by LARC who underwent radical surgery and adjuvant chemoradiation, tumour Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: Angiogenic markers of neoadjuvant chemoradiation VEGF overexpression was found to be associated with a statistically higher risk of local recurrence and metastasis (9). Not only VEGF, but placental growth factor (PlGF) are potentially useful predictive factors in rectal cancer (10).…”
Section: Introductionmentioning
confidence: 99%
“…VEGF and its receptor are also expressed at high levels in metastatic human colon cancers and in tumor-associated endothelial cells (14). Takahashi et al (24) showed that the VEGF expression levels in patients with lymph node-negative colon cancer were significantly related to the time to recurrence, while Gascinu et al (15) noted that p53 and VEGF were both expressed in node-positive rectal cancer. The majority of disease-free patients showed p53-negative and VEGF-negative tumors, while distant metastases were seen in patients with VEGF positive tumors (15).…”
Section: Discussionmentioning
confidence: 99%
“…In particular, vascular endothelial growth factor (VEGF) is a multifunctional cytokine that potently stimulates angiogenesis, including tumor neovascularization (13). Recent studies have revealed relationships among an increased expression of VEGF, distant metastasis, and poor prognoses of patients with colorectal cancer (14,15). Induction of VEGF expression, in vivo and in vitro, after exposure to ionizing radiation, was recently reported (16,17).…”
Section: Introductionmentioning
confidence: 99%