An analysis of Ewing's tumor in children at Roswell Park Memorial Institute

Abstract

Twenty pediatric patients with Ewing's tumor seen at Roswell Park Memorial Institute, from 1954 to 1970, have been analyzed. Three patients are considered as cures. As the initial treatment, these three patients were all treated with radiotherapy to the primary tumor and adjuvant chemotherapy. Nine of the 20 patients were treated in this fashion. It was felt that the chemotherapy eradicated the subclinical micrometastasis and thus effected a cure. Five cases with reactivation of primary sites prior to, or simultaneous with, metastasis were noted, indicating incomplete sterilization of tumor by present radiotherapeutic techniques and also suggesting that more aggressive therapy be directed to the primary site along with the systemic chemotherapy.

Ewing’s Sarcoma of the Sternum: A Case Report and Literature Review

“…ranging from 12 to 73 cases (totaling 537 cases) of this cancer[8][9][10][11][12][13][14][15][16][17].…”

Curability of ewing's sarcoma and considerations for future therapeutic trials

“…Eight patients presenting with metastatic disease had complete responses to T-2 chemotherapy, but 7/g with metastatic disease eventually had tumor recurrence. Examination of the treatment failures, both those patients relapsing after adjuvant chemotherapy for primary Ewing's sarcoma (5), and those relapsing after having a complete response of metastatic disease (7) to T-2 chemotherapy, revealed that all relapses occurred at the end of the second year of T-2 chemotherapy o r after chemotherapy was stopped. In addition, of 23 patients receiving "curative" radiation therapy to their primary tumor, 5 had local recurrence (22%) and 6 (26%) had severe functional debility secondary to combined radiation therapy and T-2 chemotherapy.…”