volume 18, issue 8, P4433-4443 1998
DOI: 10.1128/mcb.18.8.4433
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Abstract: Nonmethylated CpG islands are generally located at the 5 ends of genes, but a CpG island in the mouse major histocompatibility complex class II I-A␤ gene is remote from the promoter and covers exon 2. We have found that this CpG island includes a novel intronic promoter that is active in embryonic and germ cells. The resulting transcript potentially encodes a severely truncated protein which would lack the signal peptide and external ␤ 1 domains. The functional significance of the internal CpG island may be t…

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