An alternative food challenge in oral allergy syndrome*1

Alonso, Ricardo; Enrique, Ernesto; Miguel-Moncı́n, M. San; Tella, R.; Fernández-Parra, B; Bartra, Joan; Cisteró-Bahíma, A.

doi:10.1016/j.jaci.2003.12.555

Cited by 3 publications

(3 citation statements)

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“…A single common protocol, based on a previous European multicenter study, was adhered to in the 3 centers. 4 Patients who had systemic reactions or anaphylaxis were also challenged, but they were started with a modified schedule proposed by Alonso et al, 12 after which they continued with the normal protocol, always within the double-blind, placebo-controlled schedule.…”

Section: Dbpcfcmentioning

confidence: 99%

Sublingual immunotherapy for hazelnut food allergy: A randomized, double-blind, placebo-controlled study with a standardized hazelnut extract

Enrique

Pineda

Malek

et al. 2005

Journal of Allergy and Clinical Immunology

376

259

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Section: Dbpcfcmentioning

confidence: 99%

Sublingual immunotherapy for hazelnut food allergy: A randomized, double-blind, placebo-controlled study with a standardized hazelnut extract

Enrique

Pineda

Malek

et al. 2005

Journal of Allergy and Clinical Immunology

376

259

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“…Intervals between doses were 20–30 min. After the last concentration intake (400 mg/ml), we continued doubling doses until symptoms appeared or until 25 g of food had been administered in a single dose [15]. …”

Section: Methodsmentioning

confidence: 99%

An Observational Study on Outgrowing Food Allergy during Non-Birch Pollen-Specific, Subcutaneous Immunotherapy

Alonso

Enrique

Pineda

et al. 2007

Int Arch Allergy Immunol

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Background: Birch pollen-specific immunotherapy (SIT) decreases allergy to foods containing birch pollen-homologous allergens. Cross-reactivity was also observed between plane tree pollen and some vegetable foods. Objective: The aim of this study was to evaluate the outgrowing of food allergy by patients suffering from vegetable food allergy associated with plane tree pollinosis (rhinoconjunctivitis and/or asthma) during plane tree pollen SIT. Methods: An observational and prospective study was conducted in 16 adult patients suffering from vegetable food allergy (hazelnut, walnut, lettuce, peach and cherry) and from plane tree pollinosis receiving plane tree pollen SIT for 1 year. Open oral challenges with the implicated food were performed before and after SIT. Blood samples were drawn for measurement of pollen- and food-specific IgE and IgG4 before and after treatment. Results: Plane tree SIT resulted in a significant decrease in food allergy, since the mean food quantity provoking objective symptoms increased from 2.19 to 13.74 g (p < 0.05), and 6 of the 11 patients tolerated the highest level (25 g) of the challenged food after plane tree SIT. Laboratory data also showed a decrease in IgE levels and an increase in IgG4 levels after immunotherapy. Conclusion: SIT with plane tree pollen has a positive impact on food allergy in plane tree pollen-allergic subjects.

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“…One problem is that the excipient and taste disguise may provoke the loss of the foods´ allergenic properties. But the food implicated must be administered naturally, not dehydrated, freeze-dried or in pills, since contact with the oral mucosa is necessary to induce the symptoms (19). Finally, due to the severity of the symptoms in some patients, this test could be potentially dangerous.…”

Section: Diagnostic Datamentioning

confidence: 99%