An acid-labile temperature-responsive sol–gel reversible polymer for enhanced gene delivery to the myocardium and skeletal muscle cells

Polymers in Small-Interfering RNA Delivery

“…These complexes displayed enhanced intracellular uptake and silencing effect of siRNA in cancer cells under applied magnetic force. Pluronic, an amphiphilic tri-block copolymer consisting of poly-(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO), is wellknown for its biocompatibility (Kwon et al, 2009;Namgung et al, 2009b;Garripelli et al, 2010). Pluronic derivatives and oleic acid-coated iron oxide nanocrystals in an organic solvent were ultrasonically emulsified in an aqueous PEI solution.…”

Redispersible dried hydroxyapatite particles with grafted pH-sensitivity polymer brushes of poly(styrene-co-4-vinylpyridine)

“…Recently, stimuli-responsive hybrid particles had raised great interests in a wide range of fields, for example, microfluidic devices [6][7][8], assembly of nanoparticles [9], chemical gates [10][11][12] and responsive colloids [13][14][15][16][17][18][19][20][21][22][23][24]. Surface modification of nanoparticles with a stimuli-responsive shell had been explored to investigate the reversible response of nanoparticles to altering external stimuli/ signals [13,14], such as pH value [15][16][17][18], temperature [19][20][21][22] and light [23][24][25].…”

Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine

“…Recently, a multiblock copolymer of Pluronic ® based on acid labile acetal linkages was created by reaction of Pluronic ® and di-(ethylene glycol) divinylether (DEGDVE) in the presence of a p -toluenesulfonic anhydride ( p -TSA) catalyst [49]. Its hydrolytic degradation rate increased with decreasing pH, and the hydrolysis of the hydrogels released Pluronic ® , diethylene glycol and acetaldehyde, which do not decrease the pH of the surrounding environment [50]. …”