Amyotrophic Lateral Sclerosis With Objective and Subjective (Neuritic) Sensory Disturbances

Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

“…Consequently, the occasional presence of sensory features in ALS has long been a cause of diagnostic uncertainty. 9 We report five cases of ALS with a coexistent sensory neuropathy for which an alternative cause could not be identified. We propose that sensory nerve degeneration may represent part of the clinical spectrum of ALS.…”

Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

“…Consequently, the occasional presence of sensory features in ALS has long been a cause of diagnostic uncertainty. 9 We report five cases of ALS with a coexistent sensory neuropathy for which an alternative cause could not be identified. We propose that sensory nerve degeneration may represent part of the clinical spectrum of ALS.…”

Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives

“…A spinocerebellar pathway (Clarke's column) taking origin in the spinal cord segments is consistently affected in pathological studies of ALS, which may underlie the early symptom of impaired balance often reported by patients at diagnosis [ 90 ]. In addition, clinicians have long noted minor sensory and autonomic involvement in patients with ALS [ 91 ] and small fiber neuropathy was found in skin biopsies in 79% of ALS patients [ 92 ]. The link between ALS and frontotemporal dementia represents an extension of ALS as a motor system disease to the frontal and temporal lobes, which are brain areas involved in the expression of thought, planning, personality, and speech, all aspects of brain function that may interfere with pain perception [ 93 ].…”

The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey

“…In addition, clinicians have long noted minor sensory and autonomic involvement in patients with ALS. 26 Overlap between mild Parkinsonian features and ALS were well documented, 27 and cross-over phenotypes have re-emerged within the spectrum of ALS linked to C9orf72 expansions. 28 The Guamanian ALS-Parkinson's-dementia complex represents an extreme, not least since it appears to be an acquired, non-genetic form of the disease.…”

Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

“…Consequently, the occasional presence of sensory features in ALS has long been a cause of diagnostic uncertainty. 9 We report five cases of ALS with a coexistent sensory neuropathy for which an alternative cause could not be identified. We propose that sensory nerve degeneration may represent part of the clinical spectrum of ALS.…”

Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives

“…A spinocerebellar pathway (Clarke's column) taking origin in the spinal cord segments is consistently affected in pathological studies of ALS, which may underlie the early symptom of impaired balance often reported by patients at diagnosis [ 90 ]. In addition, clinicians have long noted minor sensory and autonomic involvement in patients with ALS [ 91 ] and small fiber neuropathy was found in skin biopsies in 79% of ALS patients [ 92 ]. The link between ALS and frontotemporal dementia represents an extension of ALS as a motor system disease to the frontal and temporal lobes, which are brain areas involved in the expression of thought, planning, personality, and speech, all aspects of brain function that may interfere with pain perception [ 93 ].…”

The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey

“…In addition, clinicians have long noted minor sensory and autonomic involvement in patients with ALS. 26 Overlap between mild Parkinsonian features and ALS were well documented, 27 and cross-over phenotypes have re-emerged within the spectrum of ALS linked to C9orf72 expansions. 28 The Guamanian ALS-Parkinson's-dementia complex represents an extreme, not least since it appears to be an acquired, non-genetic form of the disease.…”

Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

“…Consequently, the occasional presence of sensory features in ALS has long been a cause of diagnostic uncertainty. 9 We report five cases of ALS with a coexistent sensory neuropathy for which an alternative cause could not be identified. We propose that sensory nerve degeneration may represent part of the clinical spectrum of ALS.…”

Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives

“…A spinocerebellar pathway (Clarke's column) taking origin in the spinal cord segments is consistently affected in pathological studies of ALS, which may underlie the early symptom of impaired balance often reported by patients at diagnosis [ 90 ]. In addition, clinicians have long noted minor sensory and autonomic involvement in patients with ALS [ 91 ] and small fiber neuropathy was found in skin biopsies in 79% of ALS patients [ 92 ]. The link between ALS and frontotemporal dementia represents an extension of ALS as a motor system disease to the frontal and temporal lobes, which are brain areas involved in the expression of thought, planning, personality, and speech, all aspects of brain function that may interfere with pain perception [ 93 ].…”

The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey

“…In addition, clinicians have long noted minor sensory and autonomic involvement in patients with ALS. 26 Overlap between mild Parkinsonian features and ALS were well documented, 27 and cross-over phenotypes have re-emerged within the spectrum of ALS linked to C9orf72 expansions. 28 The Guamanian ALS-Parkinson's-dementia complex represents an extreme, not least since it appears to be an acquired, non-genetic form of the disease.…”