Amyloidosis of the Head and Neck: A Clinicopathologic Study of the UCLA Experience, 1955-1991

Oral manifestations of amyloidosis and the diagnostic applicability of oral tissue biopsy

“…The clinical manifestations of amyloidosis in the oral cavity found herein are in agreement with previous studies 1,9,19,20 . Macroglossia, in addition to nodules, tumors, papules, and swelling located mainly in/on the tongue and in multiple sites as well as a variation in the color of the oral mucosa, with emphasis on the yellowish color, are the main clinical features found in our patients.…”

“…Despite this, the current sample is one of the most extensive series in the literature. The age distribution found herein is in line with data described in most of studies, with an average age of around 56 years 1,9,19,20 . Most patients were men, but there is no consensus regarding sex, as some studies report a predominance of female patients 1,6,9 …”

“…The prevalence of amyloidosis‐related oral biopsies diagnosed in three Brazilian oral pathology services was low in the present study. The prevalence is not precisely determined in the literature, which impedes comparisons 1,6,9,19,20 . Despite this, the current sample is one of the most extensive series in the literature.…”

Head and neck amyloidosis: clinicopathological features and immunohistochemical analysis of 14 cases

“…However, it is not always the rule, as AL-amyloidosis cases associated with chronic infectious diseases may also be found (14). Nodular amyloidosis, mostly composed of monoclonal light chain immunoglobulins, more commonly affects the head and neck region as previously commented (4,(9)(10)(11)(12)(13). In the current series, it was present as isolated nodules on the dorsum of the tongue, hard palate, and buccal mucosa ( Table 1).…”

“…Nodular amyloidosis, mostly composed of monoclonal light chain immunoglobulins, more commonly affects the head and neck region as previously commented (4, 9–13). In the current series, it was present as isolated nodules on the dorsum of the tongue, hard palate, and buccal mucosa (Table 1).…”