Amyloidosis Cutis

Genome-wide scan identifies a susceptibility locus for familial primary cutaneous amyloidosis on chromosome 5p13.1-q11.2

“…[6][7][8] While most cases of PCA are sporadic, some patients have a family history. [9][10][11][12][13][14][15][16][17][18][19][20] Ollague et al 6 reported that about one-third of the cases of PCA in South America have a family history of this disorder. In Southeast Asia, significantly more Chinese have been noted to be affected with PCA than Malays and Indians.…”

“…While most cases of PCA are sporadic, some patients have a family history 9–20 . Ollague et al 6 reported that about one‐third of the cases of PCA in South America have a family history of this disorder.…”

Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis

“…[7][8][9][10][11][12][13][14][15][16][17][18] Notably, Ollague et al 2 reported that about one-third of the cases of PCA in South America have a positive family history. In Southeast Asia, familial PCA (FPCA) is also prevalent, especially in Chinese families, more so than in Malays and Indians.…”

Familial primary cutaneous amyloidosis in a South African family

“…The ®rst two reports were South American. 4,5 One family each came from Russia, 6 Germany, 7 Puerto Rico, 8 England, 9 Italy 10 and Japan. 2 Families from Singapore 11 and Malaysia 3 were ethnic Chinese.…”