volume 27, issue 4, P701-709 2011
DOI: 10.3233/jad-2011-110890
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Ana Lloret, Mari-Carmen Badia, Esther Giraldo, Gennady Ermak, Maria-Dolores Alonso, Federico V. Pallardó, Kelvin J.A. Davies, Jose Viña

Abstract: Amyloid-β peptide (Aβ) toxicity and tau hyperphosphorylation are hallmarks of Alzheimer’s disease (AD). How their molecular relationships may affect the etiology, progression, and severity of the disease, however, has not been elucidated. We now report that incubation of foetal rat cortical neurons with Aβ up-regulates expression of the Regulator of Calcineurin gene RCAN1, and this is mediated by Aβ-induced oxidative stress. Calcineurin (PPP3CA) is a serine-threonine phosphatase that dephosphorylates tau. RCA…

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