Amyloid Prefibrillar Oligomers: The Surprising Commonalities in Their Structure and Activity

Diociaiuti, Marco; Bonanni, Roberto; Cariati, Ida; Frank, Claudio; D’Arcangelo, Giovanna

doi:10.3390/ijms22126435

Cited by 20 publications

(14 citation statements)

References 204 publications

(286 reference statements)

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“…Brain adaptations to WBV could also involve multiple brain regions in humans, given the close communication between the sensory systems of vibration perception and the areas that oversee cognitive functions [ 33 ]. In this regard, Regterschot et al investigated the acute effects of passive WBV on executive functions in 133 healthy young adults subjected to six training sessions (frequency 30 Hz, amplitude approximately 0.5 mm) alternating with six rest sessions of two minutes each.…”

Section: Physiological Adaptations To Wbvmentioning

confidence: 99%

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Bonanni

Cariati

Romagnoli

et al. 2022

JFMK

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Several studies agree that mechanical vibration can induce physiological changes at different levels, improving neuromuscular function through postural control strategies, muscle tuning mechanisms and tonic vibration reflexes. Whole-body vibration has also been reported to increase bone mineral density and muscle mass and strength, as well as to relieve pain and modulate proprioceptive function in patients with osteoarthritis or lower back pain. Furthermore, vibratory training was found to be an effective strategy for improving the physical performance of healthy athletes in terms of muscle strength, agility, flexibility, and vertical jump height. Notably, several benefits have also been observed at the brain level, proving to be an important factor in protecting and/or preventing the development of age-related cognitive disorders. Although research in this field is still debated, certain molecular mechanisms responsible for the response to whole-body vibration also appear to be involved in physiological adaptations to exercise, suggesting the possibility of using it as an alternative or reinforcing strategy to canonical training. Understanding these mechanisms is crucial for the development of whole body vibration protocols appropriately designed based on individual needs to optimize these effects. Therefore, we performed a narrative review of the literature, consulting the bibliographic databases MEDLINE and Google Scholar, to i) summarize the most recent scientific evidence on the effects of whole-body vibration and the molecular mechanisms proposed so far to provide a useful state of the art and ii) assess the potential of whole-body vibration as a form of passive training in place of or in association with exercise.

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Section: Physiological Adaptations To Wbvmentioning

confidence: 99%

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Bonanni

Cariati

Romagnoli

et al. 2022

JFMK

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“…However, this finding does not apply to all of IDE’s substrates. The self-assembly of IDE’s amyloidogenic substrates has been shown to be enhanced by anionic lipids in membranes. ,,, Zhang et al showed that even low levels of anionic lipids promote the aggregation of cationic IAPP and facilitate IAPP-induced leakage of membranes . Clusters of anionic GM1 gangliosides in membranes accelerate Aβ aggregation to form assemblies with increased cytotoxicity .…”

Section: Resultsmentioning

confidence: 99%

Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes

et al. 2022

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Insulin-degrading enzyme (IDE) is an evolutionarily conserved ubiquitous zinc metalloprotease implicated in the efficient degradation of insulin monomer. However, IDE also degrades monomers of amyloidogenic peptides associated with disease, complicating the development of IDE inhibitors. In this work, we investigated the effects of the lipid composition of membranes on the IDE-dependent degradation of insulin. Kinetic analysis based on chromatography and insulin’s helical circular dichroic signal showed that the presence of anionic lipids in membranes enhances IDE’s activity toward insulin. Using NMR spectroscopy, we discovered that exchange broadening underlies the enhancement of IDE’s activity. These findings, together with the adverse effects of anionic membranes in the self-assembly of IDE’s amyloidogenic substrates, suggest that the lipid composition of membranes is a key determinant of IDE’s ability to balance the levels of its physiologically and pathologically relevant substrates and achieve proteostasis.

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“…Indeed, a misfolding event has been proposed as the underlying mechanism that involves the assumption by a specific protein of an incorrect conformation. This initial event causes the misfolded proteins to aggregate into increasingly large species with a high neurotoxic potential, leading to progressive neuronal loss in certain brain areas [ 79 ].…”

Section: Physical Exercise As a Non-pharmacological Strategy To Preve...mentioning

confidence: 99%

Physical Exercise and Health: A Focus on Its Protective Role in Neurodegenerative Diseases

Bonanni

Cariati

Tarantino

et al. 2022

JFMK

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Scientific evidence has demonstrated the power of physical exercise in the prevention and treatment of numerous chronic and/or age-related diseases, such as musculoskeletal, metabolic, and cardiovascular disorders. In addition, regular exercise is known to play a key role in the context of neurodegenerative diseases, as it helps to reduce the risk of their onset and counteracts their progression. However, the underlying molecular mechanisms have not yet been fully elucidated. In this regard, neurotrophins, such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glia cell line-derived neurotrophic factor (GDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), have been suggested as key mediators of brain health benefits, as they are involved in neurogenesis, neuronal survival, and synaptic plasticity. The production of these neurotrophic factors, known to be increased by physical exercise, is downregulated in neurodegenerative disorders, suggesting their fundamental importance in maintaining brain health. However, the mechanism by which physical exercise promotes the production of neurotrophins remains to be understood, posing limits on their use for the development of potential therapeutic strategies for the treatment of neurodegenerative diseases. In this literature review, we analyzed the most recent evidence regarding the relationship between physical exercise, neurotrophins, and brain health, providing an overview of their involvement in the onset and progression of neurodegeneration.

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Amyloid Prefibrillar Oligomers: The Surprising Commonalities in Their Structure and Activity

Cited by 20 publications

References 204 publications

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes

Physical Exercise and Health: A Focus on Its Protective Role in Neurodegenerative Diseases

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