Laure Saint-Aubert, Mélanie Planton, Didier Hannequin, Jean-François Albucher, Marie-Bernadette Delisle, Pierre Payoux, Anne Hitzel, Gérard Viallard, Patrice Péran, Dominique Campion, Annie Laquerrière, Emmanuel J. Barbeau, Michéle Puel, Nicolas Raposo et al.
Abstract:We report the case of a 62-year-old asymptomatic carrier of AβPP gene duplication. He was investigated by MRI and the amyloid ligand (18)F-AV45, and compared to Alzheimer's disease patients (n = 11) and healthy controls (n = 11). The neuropsychological examination was normal. Cortical thickness and AV45 retention were comparable to Alzheimer's disease patients. AβPP duplication was diagnosed because cerebral amyloid angiopathy and Alzheimer's disease pathology were found on the neuropathological examination of…
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