volume 24, issue s2, P61-73 2011
DOI: 10.3233/jad-2011-102139
View full text
|
Sign up to set email alerts
|
Share

Abstract: An imbalance between production and clearance of the amyloid-β peptide (Aβ) is a key momentum of the complex pathological cascade of Alzheimer's disease (AD). It is caused by overproduction of Aβ or, more frequently, by impaired clearance from brain. Clearance can be reduced by increased aggregation, defective degradation, disturbed balance of transport across the blood-brain barrier, or inefficient peripheral removal of the peptide. In recent years these mechanisms have become targets of pharmacological inter…

Expand abstract

Search citation statements

Order By: Relevance

Citation Types

0
38
0
1

Paper Sections

0
0
0
0
0

Publication Types

0
0
0
0

Relationship

0
0

Authors

Journals