Amygdalin mediates relieved atherosclerosis in apolipoprotein E deficient mice through the induction of regulatory T cells

The Effect of Amygdalin on Endoplasmic Reticulum (ER) Stress Induced Hepatic Steatosis in Mice

“…Heikkila, Cabbat (23) have previously reported that amygdalin pretreatment before alloxan-induced diabetes decreases the blood glucose by reactive hydroxyl radical scavenging. In another study, the potential effects of amygdalin in prevention of aortic atherosclerotic plaques and other vessels have been reported (21,22). Nevertheless, our results showed that, at least in the liver, amygdalin did not improve ER stress induced steatosis.…”

“…Our other findings reported that amygdalin decreased the plasma TG and TC levels after the TM challenge. It has been revealed that amygdalin decreased TG, TC, and low-density lipoprotein in ApoE (−/−) mice (22). Zhao, Yang (21) also reported the protective effect of amygdalin in atherosclerosis development after one-month high fat diet.…”

“…Several studies have also demonstrated the apoptotic and anticancer effects of amygdalin in various cells lines and tissues (18)(19)(20). Furthermore, amygdalin reveals attenuating effects on atherosclerosis in mice (21,22).…”

“…It has been demonstrated that amygdalin reduced the proinflammatory cytokines such TNF-α, IL1, monocyte chemo-attractant protein-1 (MCP1), and inhibited toll-like receptor2 (TLR2) and TLR4 (27,29). In another study, Jiagang et al (22) have been shown that the antiatherosclerotic effect of amygdalin is mediated through the induction of regulatory T cells. Collectively, it is presumed that these findings delineate the amygdalin inhibitory effects on the inflammation processes in the liver; however, ample evidence is required to clarify the precise mechanism.…”

Effect of Amygdalin on the treatment and recurrence of endometriosis in an experimental rat study

“…It has been thought that amygdalin is also an anti-inflammatory agent (10). A recent study by Jiagang et al showed the influence of amygdalin on the regulation of immune system cells during the development of atherosclerosis (11). It has been proposed that amygdalin could affect the local activity of immune cells which are crucial pathogenic factors in the development and progression of endometriosis (12).…”