Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents

Ernst, Monique; Nelson, Eric E.; Jazbec, Sandra; McClure, Erin B.; Monk, Christopher S.; Leibenluft, Ellen; Blair, R. J. R.; Pine, Daniel S.

doi:10.1016/j.neuroimage.2004.12.038

Cited by 570 publications

(589 citation statements)

References 63 publications

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“…The notion that adolescents suffer from a "reward deficiency syndrome," although intuitively appealing, is undermined by several studies that indicate elevated activity in subcortical regions, especially the accumbens, in response to reward during adolescence (Ernst et al, 2005;Galvan et al, 2006). An alternative account is that the increase in sensation-seeking in adolescence is due not to functional dopamine deficits but to a temporary loss of "buffering capacity" associated with the disappearance of dopamine autoreceptors in the prefrontal cortex that serve a regulatory negative-feedback function during childhood (Dumont et al, 2004, cited in Ernst & Spear, in press).…”

Section: Remodeling Of the Dopaminergic System At Pubertymentioning

confidence: 99%

“…Little is known about changes in reward seeking after adolescence, however, and there remain inconsistencies in the literature with respect to age differences in reward sensitivity after adolescence (cf. Bjork et al, 2004;Ernst et al, 2005;Galvan et al, 2006), likely due to methodological differences between studies in the manipulation of reward salience (e.g., whether the comparison of interest is in reward versus cost or among rewards of different magnitudes) and whether the task involves the anticipation or actual receipt of the reward. Nevertheless, studies of age differences in sensation seeking (in addition to our own) show a decrease in this tendency after age 16 (Zuckerman et al, 1978), and there is some behavioral evidence (Millstein & Halpern-Felsher, 2002) suggesting that adolescents may be more sensitive than adults to variation in rewards and comparably or even less sensitive to variation in costs, a pattern borne out in our Iowa Gambling Task data (Cauffman et al, 2007).…”

Section: Why Does Risk-taking Decline Between Adolescence and Adulthood?mentioning

confidence: 99%

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A social neuroscience perspective on adolescent risk-taking

Steinberg¹

2008

Developmental Review

2,706

2,024

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This article proposes a framework for theory and research on risk-taking that is informed by developmental neuroscience. Two fundamental questions motivate this review. First, why does risktaking increase between childhood and adolescence? Second, why does risk-taking decline between adolescence and adulthood? Risk-taking increases between childhood and adolescence as a result of changes around the time of puberty in the brain's socio-emotional system leading to increased rewardseeking, especially in the presence of peers, fueled mainly by a dramatic remodeling of the brain's dopaminergic system. Risk-taking declines between adolescence and adulthood because of changes in the brain's cognitive control system -changes which improve individuals' capacity for selfregulation. These changes occur across adolescence and young adulthood and are seen in structural and functional changes within the prefrontal cortex and its connections to other brain regions. The differing timetables of these changes make mid-adolescence a time of heightened vulnerability to risky and reckless behavior.

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Section: Remodeling Of the Dopaminergic System At Pubertymentioning

confidence: 99%

Section: Why Does Risk-taking Decline Between Adolescence and Adulthood?mentioning

confidence: 99%

A social neuroscience perspective on adolescent risk-taking

Steinberg¹

2008

Developmental Review

2,706

2,024

View full text Add to dashboard Cite

show abstract

“…The amygdala was reported to facilitate reward-seeking behaviors by the glutamatergic or dopaminergic neurotransmission in the amygdala-striatum pathway (Lintas et al, 2011;Prevost et al, 2011;Stuber et al, 2011). Bilateral amygdala and nucleus accumbens showed significantly greater response to wins than to losses in both adolescents and adults (Ernst et al, 2005).…”

Section: Reward Dependencementioning

confidence: 99%

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

et al. 2014

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“…There are different stages of reward processing, and it is widely discussed whether the nucleus accumbens (NAcc) is predominantly involved in reward anticipation (see, eg, Knutson et al, 2001) or in reward outcome (see, eg, Elliott et al, 2000;Ernst et al, 2005). Given the heterogeneity of previous studies, with different paradigms focusing on different aspects of reward processing, it is difficult to gain a clear picture.…”

Section: Introductionmentioning

confidence: 99%

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Redlich

Dohm

Grotegerd

et al. 2015

Neuropsychopharmacol

138

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Differentiating bipolar disorders (BD) from unipolar depression (UD) remains a major clinical challenge. The identification of neurobiological markers may help to differentiate these disorders, particularly during depressive episodes. This cross-sectional study, including 33 patients with UD, 33 patients with BD, and 34 healthy controls, is one of the first to directly compare UD and BD with respect to reward processing. A card-guessing paradigm was employed and brain activity associated with reward processing was investigated by means of fMRI. A 3 (group) × 2 (condition: reward4control, loss4control) ANOVA was conducted using the nucleus accumbens (NAcc) as ROI. Furthermore, a whole-brain approach was applied. A functional connectivity analysis was performed to characterize diagnosis-related alterations in the functional coupling between the NAcc and other brain areas. The ANOVA revealed higher activity for healthy controls (HCs) than for BD and UD in the NAcc during reward processing. Moreover, UD showed a higher functional connectivity between the NAcc and the VTA than HC. The patients groups could be differentiated in that BD showed a decreased activation, in the reward condition, of the NAcc, caudate nucleus, thalamus, putamen, insula, and prefrontal areas compared with UD. These results may help to refine the understanding of neural correlates of reward processing in both disorders, and to understand the neural underpinnings of anhedonia, a core symptom of depressive episodes.

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Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents

Cited by 570 publications

References 63 publications

A social neuroscience perspective on adolescent risk-taking

A social neuroscience perspective on adolescent risk-taking

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

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