Amplitudes of Accommodation of Primate Lenses Refilled With Two Types of Inflatable Endocapsular Balloons

Accommodation Amplitude After Lens Refilling With Injectable Silicone by Sealing the Capsule With a Plug in Primates

“…Although we refilled the lens capsule to obtain apparently optimal accommodation amplitude, we obtained only a small fraction of the amplitude before surgery. Similar results were also obtained in our previous study 7 involving lenses refilled with inflatable endocapsular balloon. We think this may be caused by the loss of intracapsular accommodation, ie, the active participation of lens fiber cells in accommodation.…”

“…We could confirm a mean accommodation amplitude of 4.6 ± 0.5 diopters (D) in young cynomolgus monkey eyes after they were refilled by means of an inflatable endocapsular balloon. 7 Sakka et al 8 also confirmed some accommodation in 2 monkey eyes with the use of our procedure.…”

Accommodation Amplitude After Lens Refilling With Injectable Silicone by Sealing the Capsule With a Plug in Primates

“…Although we refilled the lens capsule to obtain apparently optimal accommodation amplitude, we obtained only a small fraction of the amplitude before surgery. Similar results were also obtained in our previous study 7 involving lenses refilled with inflatable endocapsular balloon. We think this may be caused by the loss of intracapsular accommodation, ie, the active participation of lens fiber cells in accommodation.…”

“…We could confirm a mean accommodation amplitude of 4.6 ± 0.5 diopters (D) in young cynomolgus monkey eyes after they were refilled by means of an inflatable endocapsular balloon. 7 Sakka et al 8 also confirmed some accommodation in 2 monkey eyes with the use of our procedure.…”

Accommodation amplitudes after an accommodating intraocular lens refilling procedure: In vivo update

“…This result is similar to the previous finding in our monkey experiments. 4,8 Koopmans, et al 10 also reported similar results of 3 to 4D of accommodation (and up to 6D) in their rhesus monkey experiments using the plug-sealing technique, a far low level compared to the preoperative value.…”

“…Another reason it may be a reduced adhesion between the lens capsule and polymerized silicone, compared to the preoperative condition, which may result in a less efficient transmission of the capsular forces that would the lens contents during accommodation. 4,10 …”

Changes of the accommodative amplitude and the anterior chamber depth after implantation of an accommodative intraocular lens

“…This concept of microsurgical recovery of the accommodative power involves removal of the lens substance through a narrow opening and refilling of the capsular bag with flexible materials, the so-called phakoersatz. For several years, various groups have made renewed attempts to develop such an artificial lens [11,17,25,26,29,31]. Flexible silicone polymers and hydrogels are being tested as potentially suitable materials for capsular bag filling.…”

Accommodation Amplitude After Lens Refilling With Injectable Silicone by Sealing the Capsule With a Plug in Primates

“…Although we refilled the lens capsule to obtain apparently optimal accommodation amplitude, we obtained only a small fraction of the amplitude before surgery. Similar results were also obtained in our previous study 7 involving lenses refilled with inflatable endocapsular balloon. We think this may be caused by the loss of intracapsular accommodation, ie, the active participation of lens fiber cells in accommodation.…”

“…We could confirm a mean accommodation amplitude of 4.6 ± 0.5 diopters (D) in young cynomolgus monkey eyes after they were refilled by means of an inflatable endocapsular balloon. 7 Sakka et al 8 also confirmed some accommodation in 2 monkey eyes with the use of our procedure.…”

Accommodation amplitudes after an accommodating intraocular lens refilling procedure: In vivo update

“…This result is similar to the previous finding in our monkey experiments. 4,8 Koopmans, et al 10 also reported similar results of 3 to 4D of accommodation (and up to 6D) in their rhesus monkey experiments using the plug-sealing technique, a far low level compared to the preoperative value.…”

“…Another reason it may be a reduced adhesion between the lens capsule and polymerized silicone, compared to the preoperative condition, which may result in a less efficient transmission of the capsular forces that would the lens contents during accommodation. 4,10 …”

Changes of the accommodative amplitude and the anterior chamber depth after implantation of an accommodative intraocular lens

“…This concept of microsurgical recovery of the accommodative power involves removal of the lens substance through a narrow opening and refilling of the capsular bag with flexible materials, the so-called phakoersatz. For several years, various groups have made renewed attempts to develop such an artificial lens [11,17,25,26,29,31]. Flexible silicone polymers and hydrogels are being tested as potentially suitable materials for capsular bag filling.…”

Accommodation Amplitude After Lens Refilling With Injectable Silicone by Sealing the Capsule With a Plug in Primates

“…Although we refilled the lens capsule to obtain apparently optimal accommodation amplitude, we obtained only a small fraction of the amplitude before surgery. Similar results were also obtained in our previous study 7 involving lenses refilled with inflatable endocapsular balloon. We think this may be caused by the loss of intracapsular accommodation, ie, the active participation of lens fiber cells in accommodation.…”

“…We could confirm a mean accommodation amplitude of 4.6 ± 0.5 diopters (D) in young cynomolgus monkey eyes after they were refilled by means of an inflatable endocapsular balloon. 7 Sakka et al 8 also confirmed some accommodation in 2 monkey eyes with the use of our procedure.…”

Accommodation amplitudes after an accommodating intraocular lens refilling procedure: In vivo update

“…This result is similar to the previous finding in our monkey experiments. 4,8 Koopmans, et al 10 also reported similar results of 3 to 4D of accommodation (and up to 6D) in their rhesus monkey experiments using the plug-sealing technique, a far low level compared to the preoperative value.…”

“…Another reason it may be a reduced adhesion between the lens capsule and polymerized silicone, compared to the preoperative condition, which may result in a less efficient transmission of the capsular forces that would the lens contents during accommodation. 4,10 …”

Changes of the accommodative amplitude and the anterior chamber depth after implantation of an accommodative intraocular lens

“…This concept of microsurgical recovery of the accommodative power involves removal of the lens substance through a narrow opening and refilling of the capsular bag with flexible materials, the so-called phakoersatz. For several years, various groups have made renewed attempts to develop such an artificial lens [11,17,25,26,29,31]. Flexible silicone polymers and hydrogels are being tested as potentially suitable materials for capsular bag filling.…”