Amplitude-Integrated Electroencephalography for Early Diagnosis and Prognostic Prediction of Hypoxic Encephalopathy in Preterm Infants

Abstract

BackgroundThe aim of this study was to analyze amplitude-integrated electroencephalography (aEEG) in early diagnosis and prognosis of hypoxic encephalopathy (HE) in premature infants.Material/MethodsThirty-six premature infants with HE who were treated in Linyi Central Hospital were enrolled into the study group, while 40 premature infants without HE were assigned into the control group. aEEG was conducted within 6 h after delivery to compare aEEG continuity, mature sleep-wake cycle, and maximum and minimum voltage in the 2 groups. Correlations between aEEG abnormalities and clinical grading, neurological prognosis, Apgar score, and blood gas were also analyzed among the premature infants with HE.ResultsCompared with the control group, there were reductions in the continuous rate of aEEG, mature sleep-wake cycle, and the minimum voltage, and an increase in the maximum voltage in the study group (all P<0.05). The study group had a higher abnormal rate of aEEG and a lower normal rate of aEEG than in the control group (both P<0.05). Spearman’s rank correlation coefficients for abnormal aEEG and clinical grade and poor neurological prognosis were 0.758 and 0.799, respectively. The sensitivity of abnormal aEEG in predicting severity of clinical grading was 100% with a specificity of 82.5%. The sensitivity of abnormal aEEG in predicting neurological prognosis was 100% with a specificity of 90.3%. The Apgar scores and blood glass pH of the infants with various abnormal rates of aEEG were significantly different at 1 min, 5 min, and 10 min after delivery (all P<0.05).ConclusionsHE in premature infants has specific aEEG characteristics, which can be used to predict the severity and prognosis of HE.

Effect of Early Nursing Intervention under Amplitude-Integrated Electroencephalography and Magnetic Resonance Images on Brain Injury in Premature Infants

“…AEEG can perform bedside monitoring for premature infants, display amplitude waves of EEG signals, and understand their neurophysiological activities. Tis method is intuitive, simple, noninvasive, and efcient [9][10][11][12]. MRI can detect small brain abnormalities and intracranial bleeding and accurately detect the scope and size of the lesion site.…”

Amplitude-integrated electroencephalography improves the predictive ability of acute bilirubin encephalopathy

“…Numerous data on neonatal brain maturity can be obtained through quantitative reading and scoring of aEEG graphics (14). In recent years, aEEG has been widely used in various fields of neonatology, such as seizure detection (15,16), preterm infants (17,18), metabolic disorder (19), brain damage (20), and hypoxic-ischemic encephalopathy (21,22). However, as a relatively new method of brain function monitoring, whether aEEG could be used to facilitate the early diagnosis of ABE is still unclear.…”