Ampicillin May Aggravate Clinical and Experimental Myasthenia Gravis

Gabapentin may be hazardous in myasthenia gravis

“…Previous in vivo investigations into the action of various drugs on abnormal neuromuscular transmission in EAMG showed that any impairment appears rapidly (5 min to 1 h) after administration. 1,24 In the present study, the deterioration in decremental response, which was accompanied in 60% of the animals by clinical deterioration, appeared as early as 90 min after GBP administration. Most animals, however, displayed a detrimental effect as late as 4 h after injection.…”

“…1,2,24 Although the experimental disease is not identical to human MG, 8 there are many similarities in the immune response to antigen stimulation, histopathology, and electrophysiological change. (In rats with chronic EAMG, however, a decrement is not a consistent electrophysiological feature, 13,17 as was the case in the EAMG animals in our study).…”

Gabapentin may be hazardous in myasthenia gravis

“…Previous in vivo investigations into the action of various drugs on abnormal neuromuscular transmission in EAMG showed that any impairment appears rapidly (5 min to 1 h) after administration. 1,24 In the present study, the deterioration in decremental response, which was accompanied in 60% of the animals by clinical deterioration, appeared as early as 90 min after GBP administration. Most animals, however, displayed a detrimental effect as late as 4 h after injection.…”

“…1,2,24 Although the experimental disease is not identical to human MG, 8 there are many similarities in the immune response to antigen stimulation, histopathology, and electrophysiological change. (In rats with chronic EAMG, however, a decrement is not a consistent electrophysiological feature, 13,17 as was the case in the EAMG animals in our study).…”

Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis

“…Clinical signs worsened after the dog was initially treated with amoxicillin, ampicillin, and enrofloxacin. Reports in people suggest both classes of antmicrobials may be associated with exacerbation of muscle weakness in patients with myasthenia gravis; however, no reports exist in the literature implicating meropenem deterioration of patients with myasthenia gravis. The use of meropenem may have inadvertently resulted in improvement of the clinical signs of dysphagia after the dog's second discharge from the UW‐VMTH.…”

A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics

“…There are many medications that are known to interfere with neuromuscular transmission, and this has been seen in patients with and without a previous diagnosis of MG. [4] Fluroqinolones, aminoglycosides, macrolides, and beta-lactams are common antibiotics that have been reported to exacerbate symptoms of MG. Aminoglycosides are known to have the most potent effect on neuromuscular transmission as they exert a combined presynaptic and postsynaptic effect. [5] The drug competes with calcium for receptors and hinders the release of acetylcholine from the presynaptic membrane.…”

“…The action potential of the myocyte membrane cannot form, which results in a blockade to the NMJ. [5] Aminoglycosides have also been described in the literature to cause a form of drug-induced myasthenic syndrome [4]. This syndrome is described as a reversible myasthenic disorder in patients with no evidence of a preexisting defect in neuromuscular transmission.…”

Gabapentin may be hazardous in myasthenia gravis

“…Previous in vivo investigations into the action of various drugs on abnormal neuromuscular transmission in EAMG showed that any impairment appears rapidly (5 min to 1 h) after administration. 1,24 In the present study, the deterioration in decremental response, which was accompanied in 60% of the animals by clinical deterioration, appeared as early as 90 min after GBP administration. Most animals, however, displayed a detrimental effect as late as 4 h after injection.…”

“…1,2,24 Although the experimental disease is not identical to human MG, 8 there are many similarities in the immune response to antigen stimulation, histopathology, and electrophysiological change. (In rats with chronic EAMG, however, a decrement is not a consistent electrophysiological feature, 13,17 as was the case in the EAMG animals in our study).…”

Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis

“…Clinical signs worsened after the dog was initially treated with amoxicillin, ampicillin, and enrofloxacin. Reports in people suggest both classes of antmicrobials may be associated with exacerbation of muscle weakness in patients with myasthenia gravis; however, no reports exist in the literature implicating meropenem deterioration of patients with myasthenia gravis. The use of meropenem may have inadvertently resulted in improvement of the clinical signs of dysphagia after the dog's second discharge from the UW‐VMTH.…”

A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics

“…There are many medications that are known to interfere with neuromuscular transmission, and this has been seen in patients with and without a previous diagnosis of MG. [4] Fluroqinolones, aminoglycosides, macrolides, and beta-lactams are common antibiotics that have been reported to exacerbate symptoms of MG. Aminoglycosides are known to have the most potent effect on neuromuscular transmission as they exert a combined presynaptic and postsynaptic effect. [5] The drug competes with calcium for receptors and hinders the release of acetylcholine from the presynaptic membrane.…”

“…The action potential of the myocyte membrane cannot form, which results in a blockade to the NMJ. [5] Aminoglycosides have also been described in the literature to cause a form of drug-induced myasthenic syndrome [4]. This syndrome is described as a reversible myasthenic disorder in patients with no evidence of a preexisting defect in neuromuscular transmission.…”

Gabapentin may be hazardous in myasthenia gravis

“…Previous in vivo investigations into the action of various drugs on abnormal neuromuscular transmission in EAMG showed that any impairment appears rapidly (5 min to 1 h) after administration. 1,24 In the present study, the deterioration in decremental response, which was accompanied in 60% of the animals by clinical deterioration, appeared as early as 90 min after GBP administration. Most animals, however, displayed a detrimental effect as late as 4 h after injection.…”

“…1,2,24 Although the experimental disease is not identical to human MG, 8 there are many similarities in the immune response to antigen stimulation, histopathology, and electrophysiological change. (In rats with chronic EAMG, however, a decrement is not a consistent electrophysiological feature, 13,17 as was the case in the EAMG animals in our study).…”

Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis

“…Clinical signs worsened after the dog was initially treated with amoxicillin, ampicillin, and enrofloxacin. Reports in people suggest both classes of antmicrobials may be associated with exacerbation of muscle weakness in patients with myasthenia gravis; however, no reports exist in the literature implicating meropenem deterioration of patients with myasthenia gravis. The use of meropenem may have inadvertently resulted in improvement of the clinical signs of dysphagia after the dog's second discharge from the UW‐VMTH.…”

A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics

“…There are many medications that are known to interfere with neuromuscular transmission, and this has been seen in patients with and without a previous diagnosis of MG. [4] Fluroqinolones, aminoglycosides, macrolides, and beta-lactams are common antibiotics that have been reported to exacerbate symptoms of MG. Aminoglycosides are known to have the most potent effect on neuromuscular transmission as they exert a combined presynaptic and postsynaptic effect. [5] The drug competes with calcium for receptors and hinders the release of acetylcholine from the presynaptic membrane.…”

“…The action potential of the myocyte membrane cannot form, which results in a blockade to the NMJ. [5] Aminoglycosides have also been described in the literature to cause a form of drug-induced myasthenic syndrome [4]. This syndrome is described as a reversible myasthenic disorder in patients with no evidence of a preexisting defect in neuromuscular transmission.…”