2010
DOI: 10.1016/j.yexcr.2009.11.006
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Abstract: Amphiregulin (AREG), a ligand for epidermal growth factor receptor, is required for mammary gland ductal morphogenesis and mediates estrogen actions in vivo, emerging as an essential growth factor during mammary gland growth and differentiation. The COMMA-D β-geo (CDβgeo) mouse mammary cell line displays characteristics of normal mammary progenitor cells including the capacities to regenerate a mammary gland when transplanted into the cleared fat pad of a juvenile mouse, nuclear label retention, and the capaci… Show more

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Cited by 40 publications
(37 citation statements)
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“…8A). This finding is in good agreement with another study, where a 2-fold increase was also noted in the number of mammospheres from freshly isolated Balb/c mammary epithelial cells cultured for 4 days and for 7 days [37]. Moreover, when evaluating the size of the generated mammospheres, it was found that the first cycle mammospheres were significantly larger at day 4 for cells originating from lactating tissues (P = 0.044; Fig.…”
Section: Cells From Lactating Mammary Gland Tissues Generate More Andsupporting
confidence: 92%
See 1 more Smart Citation
“…8A). This finding is in good agreement with another study, where a 2-fold increase was also noted in the number of mammospheres from freshly isolated Balb/c mammary epithelial cells cultured for 4 days and for 7 days [37]. Moreover, when evaluating the size of the generated mammospheres, it was found that the first cycle mammospheres were significantly larger at day 4 for cells originating from lactating tissues (P = 0.044; Fig.…”
Section: Cells From Lactating Mammary Gland Tissues Generate More Andsupporting
confidence: 92%
“…These second cycle mammospheres were counted and evaluated exactly as described for the first cycle mammospheres. To calculate the mammosphere forming efficiency (MFE), the number of mammospheres was divided by the original number of single cells seeded and expressed as a percentage, exactly as previously described [37,38].…”
Section: Mammosphere Cycle Assaymentioning
confidence: 99%
“…27 Interestingly, it has been reported that amphiregulin mediated self-renewal in immortalized mouse mammary epithelial cells with stem cell characteristics. 42 It will be of great interest to further test whether AREG contributes to the TAZ-induced breast cancer stem cell properties.…”
Section: Methodsmentioning
confidence: 99%
“…In the lung, the epithelium of both healthy individuals and those with chronic lung diseases produce EGFR-binding ligands, such as EGF, transforming growth factor-a (TGF-a), heparin-binding EGF-like growth factor, and AREG (19)(20)(21)(22)(23)(24)(25)(26)(27). Structurally related to EGF, AREG has been shown to regulate morphogenesis of epithelial tissues in the embryo and proliferation of multiple cell types of adult tissues, including the epidermis, mammary gland, intestine, and lung (28)(29)(30)(31)(32)(33).In the present study, we used mice deficient in either Areg or lung epithelial-specific Egfr to determine roles for these factors in pulmonary epithelial cell proliferation, repair, and differentiation after naphthalene-induced lung injury. We hypothesized that AREG and EGFR signaling would promote lung epithelial repair and regulate epithelial cell differentiation after injury.…”
mentioning
confidence: 99%