Amphetamine-Induced Sensitization Has Little Effect on Multiple Learning Paradigms and Fails to Rescue Mice with a Striatal Learning Defect

Eldred, Kiara C.; Palmiter, Richard D.

doi:10.1371/journal.pone.0059964

Cited by 6 publications

(2 citation statements)

References 70 publications

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“…In the basic Pavlovian conditioning paradigm that we have used in several studies (24)(25)(26), mice receive 25 trials a day for 5 d in which the CS is a lever that is extended (visual and motor sound cues) for 10 s in an operant box with delivery of a US food reward at the end of the 10-s cue; there is a variable 60-s intertrial interval (ITI). The head-entry (HE) rate into the food hopper during the cue presentation minus the HE rate during the ITI is calculated as the CR.…”

Section: Predominance Of Goal-tracking Behavior In Our Pavlovian Condmentioning

confidence: 99%

Dopamine dependency for acquisition and performance of Pavlovian conditioned response

Darvas¹,

Wunsch

Gibbs³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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During Pavlovian conditioning, pairing of a neutral conditioned stimulus (CS) with a reward leads to conditioned reward-approach responses (CRs) that are elicited by presentation of the CS. CR behaviors can be sign tracking, in which animals engage the CS, or goal tracking, in which animals go to the reward location. We investigated CR behaviors in mice with only ∼5% of normal dopamine in the striatum using a Pavlovian conditioning paradigm. These mice had severely impaired acquisition of the CR, which was ameliorated by pharmacological restoration of dopamine synthesis with L-dopa. Surprisingly, after they had learned the CR, its expression decayed only gradually in following sessions that were conducted without L-dopa treatment. To assess specific contributions of dopamine signaling in the dorsal or ventral striatum, we performed virus-mediated restoration of dopamine synthesis in completely dopamine-deficient (DD) mice. Mice with dopamine signaling only in the dorsal striatum did not acquire a CR, whereas mice with dopamine signaling only in in the ventral striatum acquired a CR. The CR in mice with dopamine signaling only in the dorsal striatum was restored by subjecting the mice to instrumental training in which they had to interact with the CS to obtain rewards. We conclude that dopamine is essential for learning and performance of CR behavior that is predominantly goal tracking. Furthermore, although dopamine signaling in the ventral striatum is sufficient to support a CR, dopamine signaling only in the dorsal striatum can also support a CR under certain circumstances.

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Section: Predominance Of Goal-tracking Behavior In Our Pavlovian Condmentioning

confidence: 99%

Dopamine dependency for acquisition and performance of Pavlovian conditioned response

Darvas¹,

Wunsch

Gibbs³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…Spontaneous genetic alteration (s) near these QTLs might have been co-fixed in SAMP6 through selective breeding, leading to the alterations in the dopamine, serotonin, and LTP-related-molecule systems as described above. Since neurotransmission systems of dopamine, serotonin, and glutamate are known to affect one another [ 1 , 5 , 16 , 28 , 33 , 61 , 62 ], a genetic alteration related to these neurotransmitter pathways might trigger the multiple molecular and behavioral alterations in SAMP6. Identifying QTLs for behavioral characteristics of SAMP6 is needed to elucidate the mechanisms involved.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Senescence-Accelerated Mouse Prone 6 (SAMP6) as an Animal Model for Brain Research

Niimi

Takahashi

2014

Exp. Anim.

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The senescence-accelerated mouse (SAM) was developed by selective breeding of the AKR/J strain, based on a graded score for senescence, which led to the development of both senescence-accelerated prone (SAMP), and senescence-accelerated resistant (SAMR) strains. Among the SAMP strains, SAMP6 is well characterized as a model of senile osteoporosis, but its brain and neuronal functions have not been well studied. We therefore decided to characterize the central nervous system of SAMP6, in combination with different behavioral tests and analysis of its biochemical and pharmacological properties. Multiple behavioral tests revealed higher motor activity, reduced anxiety, anti-depressant activity, motor coordination deficits, and enhanced learning and memory in SAMP6 compared with SAMR1. Biochemical and pharmacological analyses revealed several alterations in the dopamine and serotonin systems, and in long-term potentiation (LTP)-related molecules. In this review, we discuss the possibility of using SAMP6 as a model of brain function.

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Brain Angiotensin II AT1 receptors are involved in the acute and long-term amphetamine-induced neurocognitive alterations

et al. 2015

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Amphetamine-Induced Sensitization Has Little Effect on Multiple Learning Paradigms and Fails to Rescue Mice with a Striatal Learning Defect

Cited by 6 publications

References 70 publications

Dopamine dependency for acquisition and performance of Pavlovian conditioned response

Dopamine dependency for acquisition and performance of Pavlovian conditioned response

Characterization of Senescence-Accelerated Mouse Prone 6 (SAMP6) as an Animal Model for Brain Research

Brain Angiotensin II AT1 receptors are involved in the acute and long-term amphetamine-induced neurocognitive alterations

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