Amphetamine-Induced Dopaminergic Hypersensitivity in Guinea Pigs

Abnormal regional homogeneity as potential imaging biomarker for psychosis risk syndrome: a resting-state fMRI study and support vector machine analysis

“…PRS subjects with a high probability of developing schizophrenia also exhibited wide-ranging neuropsychological deficits compared with those in patients with schizophrenia to a lesser degree. Our study revealed that the PRS subjects not only exhibited abnormal clinical symptoms, including sleep and movement disorders, which may be caused by the dysfunction of dopaminergic neurotransmission5152, but also had an increased regional functional synchronization in the right putamen, implying abnormalities of regional integration of information processing in that region. However, whether the underlying mechanism of this increase is related to the abnormalities of neural neurotransmitter systems need further investigations.…”

Behavioral sensitization: Characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats

“…There is also no evidence that behavioral sensitization is due to metabolic or other peripheral effects (Browne and Segal 1977;Kuczenski et al 1982;Kuhn and Schanberg 1977). Therefore, the sensitization reported here may be due to an AMPH-induced change(s) in the functional activity of brain catecholamine neurons (Klawans and Margolin 1975;Martres et al 1977;Segal and Mandell 1974). The nature of this putative change has not been well characterized.…”

A behavioural study of the changes in the central nervous system of mice after subchronic treatment with the selective dopamine autoreceptor agonist 3-PPP (dl-3-[3-hydroxyphenyl]-N-n-propylpiperidine)

“…Many authors have reported that the chronic treatment of several species with DA agonists such as d-amphetamine or methylamphetamine elicits a slowly increasing sensitivity to the agonist (Segal and Mandell, 1974;Klawans and Margolin, 1975;Peachy et al, 1977;Weston and Overstreet, 1976;Bailey and Jackson, 1978). A similar enhancement of response has been reported after chronic L-DOPA pretreatment (Klawans et al, 1977;Bailey et al, 1979;1981).…”