2014
DOI: 10.3233/jad-131265 View full text |Buy / Rent full text
|
|

Abstract: High folate or folic acid supplements may be detrimental to cognition in older people with low vitamin B12 levels. This topic is of global significance due to the wide distribution of food fortification programs, so prospective studies should be a high priority.

Help me understand this report

Search citation statements

Order By: Relevance
Select...
1
1
1
1
1
47
2
1

Year Published

2014
2014
2017
2017

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

1
47
2
1
Order By: Relevance
“…Evidence from the National Health and Nutrition Examination Survey reported that although higher folate was generally associated with better cognitive health, a combination of high plasma folate (>59 nmol/l) with low plasma B 12 (<148 pmol) and elevated methylmalonic acid (a B 12 -specific functional biomarker), was actually associated with poorer cognitive performance compared with individuals with normal concentrations of these biomarkers (57) . Furthermore, Moore et al (58) showed participants with high red cell folate and low serum B 12 were three times more likely to have impaired cognitive performance. In contrast, however, analysis from the Hordaland Health study failed to confirm this association in their analysis (59) .…”
Section: Evidence Linking B-vitamins With Brain Health In Ageingmentioning
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Evidence from the National Health and Nutrition Examination Survey reported that although higher folate was generally associated with better cognitive health, a combination of high plasma folate (>59 nmol/l) with low plasma B 12 (<148 pmol) and elevated methylmalonic acid (a B 12 -specific functional biomarker), was actually associated with poorer cognitive performance compared with individuals with normal concentrations of these biomarkers (57) . Furthermore, Moore et al (58) showed participants with high red cell folate and low serum B 12 were three times more likely to have impaired cognitive performance. In contrast, however, analysis from the Hordaland Health study failed to confirm this association in their analysis (59) .…”
Section: Evidence Linking B-vitamins With Brain Health In Ageingmentioning
“…Although none of the researchers from studies cited above have reported adverse effects from Bvitamin supplementation caution should be taken when recommending B-vitamins without awareness of current nutrient status due to the finding of Moore et al (2014) and Malouf et al (2008). These researchers showed that B-vitamin supplementation may be detrimental to cognition in those that have optimal levels of B12 prior to supplementation.…”
Section: B-vitaminsmentioning
“…Early reports on folic acid supplementation of vitamin B-12-deficient patients have shown that folic acid ameliorates the megaloblastic anemia and hematologic abnormalities seen in severe vitamin B-12 deficiency but has no effect on the neurologic conditions that are associated with the deficiency (14). Current evidence has suggested that excess folate intake worsens the clinical and metabolic manifestations of vitamin B-12 insufficiency as indicated by increases in the prevalences of anemia and cognitive dysfunction and the concentrations of homocysteine and methylmalonic acid in plasma (15)(16)(17)(18)(19). Hence, we hypothesized that high folate intake can modify the association between the TCN2 polymorphism and peripheral neuropathy.…”
Section: Introductionmentioning