Amniotic membrane for retinal detachment due to paravascular retinal breaks over patchy chorioretinal atrophy in pathologic myopia

Caporossi, Tomaso; Angelis, Lorenzo De; Pacini, Bianca; Rizzo, Stanislao

doi:10.1177/1120672119891415

Cited by 19 publications

(21 citation statements)

References 12 publications

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“…Here, we have demonstrated that the combination of a PRP and hAM have a synergistic effect and an enhanced clinical outcome for pathologic myopia. Although the PRP preparation represents an additional step in the surgical procedure, its use permits the reduction of post-operatory face down position from 1 week, as reported by Rizzo et al, 14 to 3 days, thus being better tolerated by the patient.…”

Section: Discussionmentioning

confidence: 92%

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Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment

Tizio

Gattazzo

Staso

et al. 2020

European Journal of Ophthalmology

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Purpose: To present a modified surgical technique, based on a combination of human amniotic membrane (hAM) patch and autologous Platelet-rich plasma (PRP) in a case of recurrent retinal detachment (RRD) due to a perivascular retinal hole over an area of staphyloma in an eye with pathologic myopia. Methods: Presenting the surgical technique with the disposal of surgical video. After performing 23-gauge pars plana vitrectomy (PPV) the hAM patch was inserted under the neuroretina through the perivascular hole and PRP was injected on top to speed up the closure of the hole. To complete the surgical procedure High Viscosity Silicon oil (5000cst) was used as tamponade. The patient was prescribed to maintain a face-down position for the first 3 days after the operation. Follow-up was evaluated through Optical coherence tomography (OCT) scans. Results: The 3 days postoperative OCT showed a flat retina with the filling of the myopic staphyloma. The hAM patch was well positioned and the retinal hole could not be identified. At 6 weeks from intervention, the site of the retinal hole at OCT scan was covered by new tissue. Silicone oil was removed 3 months later with no recurrence. Conclusion: hAM transplantation is a novel technique in case of retinal detachment recurrences to seal retinal holes over high myopic chorioretinal atrophy. The adjunctive use of PRP and high viscosity silicon oil allows to reducing the standard face-down positioning timing, representing a valid solution for elderly patients who have difficulties maintaining the position for long periods.

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Section: Discussionmentioning

confidence: 92%

“…11 Retinal hAM plug transplantation has been recently successfully used for the management of high myopic macular hole 12,13 and retinal breaks. 14,15…”

Section: Discussionmentioning

confidence: 99%

Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment

Tizio

Gattazzo

Staso

et al. 2020

European Journal of Ophthalmology

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“…They reported two cases out of two of retinal reattachment. The BCVA improved from 20/2000 to 20/250 [ 33 ].…”

Section: Outcomes Of the Human Amniotic Membrane Retinal Transplanmentioning

confidence: 99%

“…The hAM application for retinal pathologies was extended to treat large macular tears [ 31 ], high myopic retinal detachment associated with MH [ 32 ], paravascular tears [ 33 ], serous macular detachment associated with optic pits [ 34 ], complicated retinal detachment [ 30 ] and advanced age related macular degeneration (AMD) [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Applications of the Amniotic Membrane in Vitreoretinal Surgery

Caporossi

Tartaro

Bacherini

et al. 2020

JCM

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Recently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders, such as macular holes that failed to close and retinal tears. The hAM has demonstrated the induction of a recovery process of the external retinal layers involving the external limiting membrane (ELM) and the ellipsoid zone (EZ). After that, the application of the hAM for retinal pathologies was extended to large macular tears, high myopic retinal detachment associated with MH, paravascular tears, serous macular detachment associated with optic pit, complicated retinal detachment and advanced age-related macular degeneration (AMD). The hAM has shown a potential in repairing retinal tissue through a regeneration process. This review aims to highlight the use of the hAM in various vitreo-retinal surgical fields, and to confront it with other cutting-edge surgical techniques used to treat challenging vitreo-retinal pathologies.

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“…Human amniotic membrane (HAM) has been reported to be safe for intraocular use; moreover, as Rizzo et al described, it appears to promote retinal healing [6][7][8]. Lyophilization of HAM maintains its histological structure [9] and, at the same time, confers beneficial features regarding its storage, biosafety and surgical handling.…”

Section: Open Accessmentioning

confidence: 99%

Lyophilized amniotic membrane patch (LAMPatch) as a replacement of tamponades in the treatment of primary rhegmatogenous retinal detachment

Saravia¹,

Zeman²,

Berra

2020

Int J Retin Vitr

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Background The basis of retinal detachment repair is sealing the retinal breaks. In order to seal the retinal breaks, chorioretinal adhesion around these lesions has to be achieved. Laser retinopexy is not immediate thus necessitates the use of a temporal endotamponade to maintain both tissues in apposition. We propose the use of a patch of lyophilized human amniotic membrane (LAMPatch) in order to occlude the retinal tear effectively until the chorioretinal adhesion is settled, overcoming the risks and limitations of the current tamponades. Methods 23-gauge vitrectomy was performed on eyes with primary retinal detachment with single retinal breaks of less than one-hour extension. A LAMPatch was deployed over the retinal breaks after retina was repositioned with perfluorocarbon. Neither gas nor silicon oil were injected. Results Six eyes of six patients with total or partial retinal detachment were included. Retinas remained reattached in all cases until the end on follow-up (3, 5 months). Best-corrected visual acuity at 1-week postop was between 20/30 and 20/100. Neither elevations of intraocular pressure, cataracts nor signs of inflammation were registered during follow-up. No second surgeries were needed. Conclusion This technique has proven to be safe and effective in this small case series. No intraocular pressure rise, inflammation or cataracts were registered until last follow-up visit.

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Amniotic membrane for retinal detachment due to paravascular retinal breaks over patchy chorioretinal atrophy in pathologic myopia

Cited by 19 publications

References 12 publications

Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment

Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment

Applications of the Amniotic Membrane in Vitreoretinal Surgery

Lyophilized amniotic membrane patch (LAMPatch) as a replacement of tamponades in the treatment of primary rhegmatogenous retinal detachment

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