Amniotic Membrane for Reducing the Formation of Adhesions in Strabismus Surgery: Experimental Study in Rabbits

Abstract

Human amniotic membrane in rabbits led to an increase in the inflammatory process and a decrease in fibrosis formation following strabismus surgery.

Effect of Cryopreserved Amniotic Membrane on the Mechanical Properties of Skeletal Muscle after Strabismus Surgery in Rabbits

“…These data suggested that cryopreserved AM did not improve the recovery of the active muscle properties. The significant muscle stress reduction showed at 30 days AM could be related to the increase of inflammation provoked by the membrane, previously described by different authors (12,20,28,29). This phenomenon, related to the xenogenic nature of the equine AM, would reverse the anti-inflammation effect of the membrane, slowing down the muscle active properties recovery.…”

“…The use of cryopreserved amniotic membrane after strabismus surgery has been deeply studied in the literature (9,10,12,17). Among their main effects, AM reduces the tissue inflammation, neovascularization and scar formation of the muscle resected or recessed (15).…”

“…Regarding the passive behavior, several studies have demonstrated the cryopreserved membrane effectiveness for reducing postoperative adhesions and scar formation (8,12,13,20). However, no mechanical characterizations of ex vivo extraocular muscle passive properties have been described; although their histological analysis showed a fibrosis reduction when AM was used.…”

“…Among various techniques to reduce the formation of these postoperative adhesions and muscle fibrosis, the use of amniotic membrane (AM) has been widely described and numerous studies reported its positive effect as an adjunct in the strabismus surgery (7)(8)(9)(10)(11)(12)(13)(14). AM acts as a temporary biological barrier between surfaces, preventing adhesion formation.…”

Restrictive problems related to strabismus surgery

“…The use of such agents should be regarded with caution as they may also decrease the reattachment of the extraocular muscle to the scleral tissue. The role of amniotic membrane to reduce postoperative scarring is studied by different groups and conflicting results are reported about the effect of reducing postoperative scarring161718192021222324.…”