volume 282, issue 2, PE259-E269 2002
DOI: 10.1152/ajpendo.00200.2001
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Abstract: Insulin-like growth factor I (IGF-I) is an important regulator of fetal growth, and circulating concentrations are reduced in intrauterine growth-restricted (IUGR) fetuses. We investigated whether IGF-I administered into amniotic fluid could ameliorate IUGR in fetal sheep. Fetuses were assigned to control ( n = 9), IUGR+saline ( n = 12), or IUGR+IGF-I groups (daily intra-amniotic IGF-I injections of 20 μg, n = 13). IUGR was induced by placental embolization from 114 to 120 days. Treatment was from 120 to 130 …

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