Amniocentesis-Related Fetal Loss: A Cohort Study

Tongsong, Theera; Wanapirak, Chanane; Sirivatanapa, Pannee; Piyamongkol, Wirawit; Sirichotiyakul, Supatra; Yampochai, Acharawan

doi:10.1016/s0029-7844(98)00125-2

Cited by 60 publications

(46 citation statements)

References 4 publications

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“…A study conducted in Turkey found, in contrast to the findings of this study, high screening test results to be 54.9%, advanced maternal age to be 20%, and abnormal USG findings to be 16% (10). Tongsong et al, in a 1998 study, differed dramatically in their findings and reported advanced maternal age to be 86% (11). It is striking that in our study the acceptance rate of advanced maternal age as an indication was reduced and that it was screening tests and ultrasound findings that led to the prenatal diagnosis.…”

Section: Discussioncontrasting

confidence: 57%

Investigation of the diagnostic value of chromosome analysis and bacterial artificial chromosome-based array comparative genomic hybridization in prenatal diagnosis

Savlı¹,

Keskin²,

Çine³

2015

Turk J Med Sci

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Background/aim: To investigate the diagnostic value of bacterial artificial chromosome (BAC)-based array comparative genomic hybridization (CGH) and chromosome analysis in prenatal diagnosis. Materials and methods:This study included the chromosome analysis and BAC-based array CGH analysis of 140 amniocentesis samples with prenatal diagnosis indications.Results: Karyotype analysis showed trisomy 21 in 4 patients, trisomy 18 in 5 patients, monosomy X in 1 patient, and other anomalies in 3 patients. The BAC-based array CGH analysis showed 4 patients with trisomy 21, 4 patients with trisomy 18, and 1 patient with monosomy X as a numerical chromosome anomaly, while partial duplication was observed in chromosome 14 in 1 case as a structural anomaly. Conclusion:The array CGH is the most effective method available to complement cases where chromosome analysis, a gold standard in prenatal diagnosis, proves to be insufficient. Considering the inherent limitations of both methods, complementary features should be introduced in order to be able to give the most accurate data at the right time.

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Section: Discussioncontrasting

confidence: 57%

Investigation of the diagnostic value of chromosome analysis and bacterial artificial chromosome-based array comparative genomic hybridization in prenatal diagnosis

Savlı¹,

Keskin²,

Çine³

2015

Turk J Med Sci

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“…The association was statistically significant and similar for spontaneous preterm delivery and induced preterm delivery. On the contrary, other studies 13,39 have shown no difference in the rate of preterm delivery after amniocentesis.…”

Section: Preterm Deliverymentioning

confidence: 80%

Invasive Prenatal Diagnosis: Amniocentesis

Antsaklis¹,

Antsaklis²,

Theodora³

2015

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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“…In the same study, early membrane rupture was determined in only 2 cases [14]. In another similar case-controlled study, Tongsong et al compared cases who had and had not undergone amniocentesis, no statistically significant difference was determined between the groups in respect of fetal loss, placental abruption or premature birth [16]. In a study by Müler et al, there was reported to be a statistically significantly higher rate of premature birth at 24-28 weeks in the group that had undergone amniocentesis compared to the control group [15].…”

Section: Discussionmentioning

confidence: 96%

Does Amniocentesis Increase the Rates of Fetal Loss and Poor Pregnancy Outcomes?

Ercan¹,

Köstü²,

Arslan³

et al. 2016

Ann Clin Anal Med

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ÖzetAmaç: Kliniğimizde son 5 yılda amniosentez yapılan hastalarda işleme bağ-lı fetal kayıp riskinin ve kötü gebelik sonuçlarının artıp artmadığını değer-lendirmek. Gereç ve Yöntem: Bu retrospektif çalışma Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum kliniğinde 2011 Ocak ile 2015 Temmuz tarihleri arasında amniosentez yapılan 387 hastanın dosyalarından ve genetik merkezin kayıtlarından incelenerek yapıldı. Ayrıca kliniğimize kontrole gelen ve amniosentez yapılmayan düşük riskli 250 hasta kontrol grubu olarak belirlendi. Bulgular: Çalışma süresince amniosentez endikasyonu olan 688 hasta mevcuttu. Bunlardan 387 hastaya amniosentez yapıldı. %43.8 amniosentez reddetme oranı mevcuttu. En sık amniosentez endikasyonu anormal Down sendromu tarama testi iken (%57.6), 2. sık-lıkla ileri maternal yaş (%22.5) görülmektedir. Amniosentez yapılan hastaların 24'ünde (%6.2) kromozomal anormallik mevcut olup bunlar içerisinde en sık Down sendromu izlendi (%54). Amniosentez sonrası fetal kayıp 2 hastada (%0.5) görülmüştür. Toplamda kötü gebelik sonuçlarına bakıldığında amniosentez yapılanlarda 8, kontrol grubunda 5 hastada kötü gebelik sonuçları izlenmiş olup gruplar arasında istatisitksel anlamlı fark yoktu (p=0.263). Tartışma: Amniosentez günümüzde sıklıkla kullanılan invaziv prenatal tanı testidir. İşleme bağlı olarak gebelik komplikasyonlarında bir artış görülmemekte-dir. Amniosentez öncesinde hastalara mutlaka yapılacak işlem ve sonuçları hakkında detaylı danışmanlık verilmelidir. Anahtar KelimelerAmniosentez; İleri Maternal Yaş; Down Sendromu Riski Abstract Aim: To evaluate the risk of fetal loss and poor pregnancy outcomes associated with amniocentesis procedures on patients in our clinic in the last 5 years. Material and Method: This retrospective study was conducted by examining the hospital records and genetic centre records of 387 patients who underwent amniocentesis at the Gynaecology and Obstetrics

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Amniocentesis-Related Fetal Loss: A Cohort Study

Abstract: Second-trimester amniocentesis is probably not associated with a greater fetal loss rate than that of matched controls.

Cited by 60 publications

References 4 publications

Investigation of the diagnostic value of chromosome analysis and bacterial artificial chromosome-based array comparative genomic hybridization in prenatal diagnosis

Investigation of the diagnostic value of chromosome analysis and bacterial artificial chromosome-based array comparative genomic hybridization in prenatal diagnosis

Invasive Prenatal Diagnosis: Amniocentesis

Does Amniocentesis Increase the Rates of Fetal Loss and Poor Pregnancy Outcomes?

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