Amitriptyline-Perphenazine Interaction in Ambulatory Schizophrenic Patients

α-Methyldopa—Chlorpromazine Combination in Schizophrenic Patients

“…In a study of the amitriptyline-perphenazine combination in schizophrenic patients we found that less response to treatment was made by patients with long-term records of prior hospitalizations (30). In the present study, there was no significant difference between the mean durations of prior hospitalizations for patients assigned to the different treatment groups, so that the comparisons between treatment effects are not biased in this way.…”

Antipsychotic Maintenance Treatment for Patients With Schizophrenia: The Need for Placebo-Controlled Trials and The Risk of Paradigm Shifts

“…Leff and Wing 32 expressed multiple criticisms of prior studies, including inherent bias in the design and failing to measure treatment adherence. Hogarty et al 33 and Chouinard et al 34 criticized studies for enrolling diagnostically and prognostically mixed patient groups. Rifkin et al 35 noted that previous studies did not analyze samples with regard to remission status.…”

Treatment of Negative Symptoms

“…Negative symptoms secondary to depression respond to treatment of the depression per se. Although general efficacy is not robust, some patients respond to traditional antidepressant drugs (Becker 1970, 1983; Hanlon, Ota, and Kurland 1970; Simpson et al 1972; Chouinard et al 1975; Siris, van Kammen, and Docherty 1978; Prusoff et al 1979; Waehrens and Gerlach 1980). There is, of course, the theoretical concern that these medications may exacerbate schizophrenic psychosis, but evidence to date suggests this is not a frequent complication (Siris, van Kammen, and Docherty 1978).…”