Amiodarone Keratopathy

Amiodarone‐induced keratopathy in healthy dogs

“…Although we could not find either corneal or optic nerve deposits using electron microscopy due to the wide and sparse distribution, corneal deposits in the cytoplasm of the basal epithelial cells were identified by light microscopy. This is consistent with studies conducted on both humans 2 and rats 16 …”

Amiodarone‐induced keratopathy in healthy dogs

“…Although we could not find either corneal or optic nerve deposits using electron microscopy due to the wide and sparse distribution, corneal deposits in the cytoplasm of the basal epithelial cells were identified by light microscopy. This is consistent with studies conducted on both humans 2 and rats 16 …”

Severe ocular side effects of perhexilene maleate: case report.

“…'8 They appear to be identical to the membrane-bound bodies which we have demonstrated in the conjunctival and corneal epithelium from this patient, and are identical to those described in amiodarone keratophy. 7 It is not surprising, therefore, to find that the other drugs which have been implicated in causing verticillate keratopathy are all amphiphilic despite being pharmacologically different-for example, amiodarone, chloroquine, mepacrine, hydroxychloroquine, amodiaquin, and indomethacin. "' Furthermore similar intralysosomal inclusion bodies occur in Fabry's disease, a rare inherited metabolic disease in which there is a Fig.…”

Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside

“…The major side effect is the production of corneal microdeposits (> 90% of treated patients). These are very similar in appearance to vortex keratopathy, which is associated with Fabry disease (D'Amico et al, 1981;Wasielica-Poslednik et al, 2011).…”

Amiodarone‐induced keratopathy in healthy dogs

“…Although we could not find either corneal or optic nerve deposits using electron microscopy due to the wide and sparse distribution, corneal deposits in the cytoplasm of the basal epithelial cells were identified by light microscopy. This is consistent with studies conducted on both humans 2 and rats 16 …”

Severe ocular side effects of perhexilene maleate: case report.

“…'8 They appear to be identical to the membrane-bound bodies which we have demonstrated in the conjunctival and corneal epithelium from this patient, and are identical to those described in amiodarone keratophy. 7 It is not surprising, therefore, to find that the other drugs which have been implicated in causing verticillate keratopathy are all amphiphilic despite being pharmacologically different-for example, amiodarone, chloroquine, mepacrine, hydroxychloroquine, amodiaquin, and indomethacin. "' Furthermore similar intralysosomal inclusion bodies occur in Fabry's disease, a rare inherited metabolic disease in which there is a Fig.…”

Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside

“…The major side effect is the production of corneal microdeposits (> 90% of treated patients). These are very similar in appearance to vortex keratopathy, which is associated with Fabry disease (D'Amico et al, 1981;Wasielica-Poslednik et al, 2011).…”

Amiodarone‐induced keratopathy in healthy dogs

“…Although we could not find either corneal or optic nerve deposits using electron microscopy due to the wide and sparse distribution, corneal deposits in the cytoplasm of the basal epithelial cells were identified by light microscopy. This is consistent with studies conducted on both humans 2 and rats 16 …”

Severe ocular side effects of perhexilene maleate: case report.

“…'8 They appear to be identical to the membrane-bound bodies which we have demonstrated in the conjunctival and corneal epithelium from this patient, and are identical to those described in amiodarone keratophy. 7 It is not surprising, therefore, to find that the other drugs which have been implicated in causing verticillate keratopathy are all amphiphilic despite being pharmacologically different-for example, amiodarone, chloroquine, mepacrine, hydroxychloroquine, amodiaquin, and indomethacin. "' Furthermore similar intralysosomal inclusion bodies occur in Fabry's disease, a rare inherited metabolic disease in which there is a Fig.…”

Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside

“…The major side effect is the production of corneal microdeposits (> 90% of treated patients). These are very similar in appearance to vortex keratopathy, which is associated with Fabry disease (D'Amico et al, 1981;Wasielica-Poslednik et al, 2011).…”