2005
DOI: 10.1590/s0004-27302005000600010
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Abstract: Amiodarone, used in the treatment of cardiac arrhythmias, is associated with thyroid dysfunction. No reports exist on its frequency in southern Brazil, nor studies evaluating the usefulness of clinical scores to diagnose thyroid abnormalities in these patients. This study aimed at determining the prevalence of amiodarone-induced thyroid dysfunction in a representative sample from a tertiary center, to study the conditions associated to this dysfunction and to evaluate the reliability of clinical scores of hypo… Show more

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Cited by 14 publications
(9 citation statements)
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“…Our results agree with reports that could not find a relationship between AITD and dosage or duration of amiodarone treatment (4,7,8,12,13). We also could not demonstrate that a baseline cardiac condition such as Chagas' disease was associated with AITD.…”
Section: Discussionsupporting
confidence: 80%
“…Our results agree with reports that could not find a relationship between AITD and dosage or duration of amiodarone treatment (4,7,8,12,13). We also could not demonstrate that a baseline cardiac condition such as Chagas' disease was associated with AITD.…”
Section: Discussionsupporting
confidence: 80%
“…These figures are similar to the ave-rage up-to-date reported incidence of clinical dysfunctions and in accordance with data on more frequent occurrence of AIH in the regions having sufficient iodine supply [4,8]. Sixteen percent of patients developed clinical thyroid dysfunction, while 21% developed some form of sub-clinical dysfunction.…”
Section: Incidencesupporting
confidence: 91%
“…According to some reports, AIH occurs early during amiodarone treatment [3]. The incidence of amiodarone-induced thyrotoxicosis (AIT), reported up to date, is 0.003%-23%, most frequently 1%-5% [4,5,7]. AIT is more frequent in areas of low iodine ingestion by food and in men [6].…”
Section: Introductionmentioning
confidence: 99%
“…A slight and usually transient increase in serum thyrotropin (TSH) is therefore frequently observed in the first 3-4 months of therapy [6]. Incidence rates of the more severe amiodarone-induced thyrotoxicosis (AIT) and amiodarone-induced hypothyroidism (AIH) are described as being dissimilar, ranging from < 1% to 23% and 47%, respectively [7][8][9][10][11][12][13][14][15][16]. Despite these effects on thyroid hormone metabolism, many patients do not show changes in thyroid function during longterm intake of amiodarone.…”
Section: Introductionmentioning
confidence: 99%