Aminophylline for bradyasystolic cardiac arrest in adults

Hurley, Katrina; Magee, Kirk; Green, Robert C.

doi:10.1002/14651858.cd006781.pub3

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…Our search strategy retrieved 543 references and, after screening the titles and abstracts, nine systematic reviews (SRs) were found to fulfill our inclusion criteria and were considered for qualitative synthesis. [6][7][8][9][10][11][12][13][14]…”

Section: Search Resultsmentioning

confidence: 99%

What do Cochrane systematic reviews say about cardiac arrest management?

et al. 2018

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This review included nine Cochrane systematic reviews that provided a diverse range of qualities of evidence (unknown to high) regarding interventions that are used in management of cardiac arrest. High-quality evidence was found by two systematic reviews as follows: (a) increased survival until hospital discharge with continuous compression, compared with interrupted chest compression, both administered by an untrained person and (b) no difference regarding the return of spontaneous circulation, comparing aminophylline and placebo, for bradyasystolic patients under cardiac arrest. Further studies are needed in order to reach solid conclusions.

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Section: Search Resultsmentioning

confidence: 99%

What do Cochrane systematic reviews say about cardiac arrest management?

et al. 2018

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“…Hurtley et al. ( 5 ) summarized the previous clinical trials of aminophylline use for brady-asystolic cardiac arrest; most trials use an intravenous aminophylline dose of 250 mg as the loading dose. Therefore, the authors used the same dose and started the continuous infusion (0.5 mg/kg/h), which was the recommended maintenance dose for airflow obstruction with a therapeutic theophylline level (10 to 20 μg/ml).…”

Section: Discussionmentioning

confidence: 99%

Sequential Use of Aminophylline and Theophylline for Temporizing Neck Cancer-Induced Carotid Sinus Syncope

et al. 2019

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Carotid sinus syncope due to head and neck cancer is uncommon and the management is challenging. Permanent pacemaker implantation is generally considered but malnutrition with subsequent chemo-radiation increases the risk of device infection. This is a first case report of the sequential use of aminophylline and theophylline for pharmacological temporization. ( Level of Difficulty: Advanced. )

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“…The effect of aminophylline in atropine-resistant cardiac arrests has been considered as an accumulation of adenosine in the heart during cardiac arrest followed by cardiac ischemia which may reduce the effectiveness of catecholamines during resuscitation. Despite initial promising results ( 80 ), this hypothesis wasn’t confirmed in an independent meta-analysis ( 81 ).…”

Section: Theophyllinementioning

confidence: 97%

A narrative review of theophylline: is there still a place for an old friend?

Scurek,

Brat

2024

J Thorac Dis

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Background and Objective Theophylline has been used for decades in human medicine for its psychostimulant, anti-inflammatory, and bronchodilator effects. Historically, in pulmonary medicine, theophylline has been used in the treatment of obstructive pulmonary diseases such as bronchial asthma (BA) or chronic obstructive pulmonary disease (COPD). This review aims to determine whether theophylline still has its place in the therapy of obstructive pulmonary diseases or whether we can even extend its use to other diagnoses such as atropine-resistant cardiac arrests, apnea of prematurity, or others. Moreover, we also aim to determine if there is a rationale for using low-dose theophylline due to its immunomodulatory and anti-inflammatory effect, or if the future of methylxanthines lies in newly synthesized derivates of theophylline such as bamifylline, or doxofylline. Methods The narrative review is based on a literature search of the articles indexed in the PubMed database in 2023. We searched the database since the year 2009 using the MeSH terms “theophylline”, “aminophylline”, and “methylxanthines” and we included original articles in the English language. Key Content and Findings Theophylline has a number of adverse drug reactions (ADRs), the most serious of which is its effect on the cardiovascular system. It can cause severe arrhythmias or even cardiac arrest when overdosed. On the other hand, there is still a substantial amount of its applications in current clinical practice. Conclusions There is considerable controversy associated with its use in current medicine, which can be attributed both to its narrow therapeutic range and its mentioned cardiotoxic effect. Herein, we summarize the current state-of-art of theophylline and its use in human medicine.

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Aminophylline for bradyasystolic cardiac arrest in adults

Abstract: The prehospital administration of aminophylline in bradyasystolic arrest is not associated with improved return of circulation, survival to admission or survival to hospital discharge. The benefits of aminophylline administered early in resuscitative efforts are not known.

Cited by 6 publications

References 46 publications

What do Cochrane systematic reviews say about cardiac arrest management?

What do Cochrane systematic reviews say about cardiac arrest management?

Sequential Use of Aminophylline and Theophylline for Temporizing Neck Cancer-Induced Carotid Sinus Syncope

A narrative review of theophylline: is there still a place for an old friend?

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