Amino porphyrin-peptide assemblies induce ribosome damage and cancer stem cell inhibition for an enhanced photodynamic therapy

Wang, Jian; Yang, Baochan; Lv, Chunxiao; Chen, Tiancheng; Sun, Lixin; Sun, Lei; Hao, Junfeng; Ding, Fang; Wang, Tianyu; Jiang, Jianzhuang; Qin, Yan

doi:10.1016/j.biomaterials.2022.121812

Cited by 14 publications

(7 citation statements)

References 71 publications

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“…[ 23 ] The ribosomes (RPS3+) in tumor tissues were decreased in HCCO+L treated group (Figure S7, Supporting Information), which also indicated the effective elimination of CSCs at tumor site. [ 24 ]…”

Section: Resultsmentioning

confidence: 99%

Reversing Resistance of Cancer Stem Cells and Enhancing Photodynamic Therapy Based on Hyaluronic Acid Nanomicelles for Preventing Cancer Recurrence and Metastasis

Wang,

Tao,

Wang

et al. 2023

Adv Healthcare Materials

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Photodynamic therapy (PDT) is a promising approach for tumor treatment; however, the therapeutic resistance of cancer stem cells (CSCs) severely limits its efficacy and easily lead to recurrence. Herein, a hyaluronic acid (HA)‐Ce6‐Olaparib (OLA) micelle (HCCO) is developed, which combines the CSC targeting of HA, the PDT effect of Ce6, and the DNA damage repair inhibition of OLA. More importantly, HCCO induces immunogenic cell death (ICD) effects, promotes dendritic cells maturation, and alleviates myeloid‐derived suppressor cells (MDSCs) infiltration to reverse CSC resistance. As a result, HCCO not only significantly inhibits the growth of 4T1 breast cancer cells and CSCs in vitro, but also effectively inhibits tumor recurrence and metastasis in vivo. This study provides a novel strategy for preventing tumor recurrence and metastasis by the combination of inhibiting DNA damage repair, reversing CSC resistance, and enhancing PDT.

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Section: Resultsmentioning

confidence: 99%

Reversing Resistance of Cancer Stem Cells and Enhancing Photodynamic Therapy Based on Hyaluronic Acid Nanomicelles for Preventing Cancer Recurrence and Metastasis

Wang,

Tao,

Wang

et al. 2023

Adv Healthcare Materials

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“…Because their amphiphilicities are still maintained, they are capable of self-assembling in aqueous solution and acting as nanocarriers to deliver porphyrins and other active species in vivo . Even so, some porphyrins, such as Ce6, are inherently amphiphiles and can self-assemble to form nanoparticles without the addition of other hydrophilic tags. − Different types of hydrophilic tags can endow them and their self-assembles with unique advanced functionalities, for example, long circulation duration and resistance to protein adsorption in circulation in vivo from oligo (ethylene glycol), , cells and tumors targeting from peptides and glycosyls. − In addition, most of the self-assembled structures of porphyrin-hydrophilic tag amphiphiles are nanoaggregation without a bilayer membrane structure which often forms in the case of porphyrin-based lipids demonstrated by the reported documents. − …”

Section: Porphyrin-based Amphiphilesmentioning

confidence: 99%

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

Han,

Liu,

Peng

et al. 2023

Bioconjugate Chem.

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Porphyrins have been vastly explored and applied in many cutting-edge fields with plenty of encouraging achievements because of their excellent properties. As important derivatives of porphyrins, porphyrin-based amphiphiles (PBAs) not only maintain the advanced properties of porphyrins (catalysis, imaging, and energy transfer) but also possess self-assembly and encapsulation capability in aqueous solution. Accordingly, PBAs and their self-assembles have had important roles in diagnosing and treating tumors and inflammation lesions in vivo, but not limited to these. In this article, we introduce the research progress of PBAs, including their constitution, structure design strategies, and performances in tumor and inflammation lesion diagnosis and treatments. On that basis, the defects of synthesized PBAs during their application and the possible effective strategies to overcome the limitations are also proposed. Finally, perspectives on PBAs exploration are updated based on our knowledge. We hope this review will bring researchers from various domains insights about PBAs.

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“…Since TAPP can generate ROS under the laser irradiation, thereby performing oxidative damage on tumor cells. [31][32][33] ROS generation capacity of M-Cu-T was further determined utilizing a singlet oxygen sensor green fluorescent probe in vitro. As illustrated in Figure 1j, nearly no fluorescence in-tensity alterations were noticed in the solution containing PBS with or without laser irradiation (referred to "PBS" or "PBS + L," respectively), M-Cu dispersion with laser irradiation (referred to "M-Cu + L"), and M-Cu-T dispersion without laser irradiation (referred to "M-Cu-T"), indicating that ROS was not produced when the absence of TAPP or laser irradiation.…”

Section: Synthesis and Characterization Of M-cu-tmentioning

confidence: 99%

Biomimetic Nanophotosensitizer Amplifies Immunogenic Pyroptosis and Triggers Synergistic Cancer Therapy

Wang,

Qin,

Qiao

et al. 2023

Adv Healthcare Materials

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Immunotherapy is considered to be an effective treatment for cancer and has drawn extensive interest. Nevertheless, the insufficient antigenicity and immunosuppressive tumor microenvironment often cause unsatisfactory therapeutic efficacy. Herein, we develop a photo‐activated reactive oxygen species (ROS) amplifying system (defined as “M‐Cu‐T”) to induce anti‐tumor immune response by triggering a tumor‐specific immunogenic pyroptosis. In M‐Cu‐T, M1 macrophage membrane‐based vesicles are used for drug loading and tumor targeting, photosensitizers (meso‐tetra(4‐aminophenyl) porphyrin, TAPP) are used as a pyroptosis inducer, copper ions (Cu2+) can enhance ROS‐induced pyroptosis by consuming antioxidant systems in cells. As expected, the prepared M‐Cu‐T targets enrichment into tumor cells and cascades the generation of ROS, which further induces pyroptosis through caspase 3‐mediated gasdermin E (GSDME) cleavage under laser activation. The pyroptotic cancer cells accompanyingly secrete related pattern molecules, induce immunogenic cell death, and activate anti‐tumor immunity for immunotherapy. An effective tumor ablation is observed in LLC and CT26 cancer mouse model. This study provides inspiration for boosting the immunogenicity and achieving satisfactory therapeutic effect in cancer therapy.This article is protected by copyright. All rights reserved

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Amino porphyrin-peptide assemblies induce ribosome damage and cancer stem cell inhibition for an enhanced photodynamic therapy

Cited by 14 publications

References 71 publications

Reversing Resistance of Cancer Stem Cells and Enhancing Photodynamic Therapy Based on Hyaluronic Acid Nanomicelles for Preventing Cancer Recurrence and Metastasis

Reversing Resistance of Cancer Stem Cells and Enhancing Photodynamic Therapy Based on Hyaluronic Acid Nanomicelles for Preventing Cancer Recurrence and Metastasis

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

Biomimetic Nanophotosensitizer Amplifies Immunogenic Pyroptosis and Triggers Synergistic Cancer Therapy

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